Okun I - Search Results

1

COS-7 cells stably transfected to express the human ETB receptor provide a useful screen for endothelin receptor antagonists.

Stavros FD, Hasel KW, Okun I, Baldwin J, Freriks K. Stavros FD, et al. Among authors: okun i. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S34-7. doi: 10.1097/00005344-199322008-00011. J Cardiovasc Pharmacol. 1993. PMID: 7509982

2

Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Castillo RS. Wu C, et al. Among authors: okun i. J Med Chem. 1997 May 23;40(11):1682-9. doi: 10.1021/jm9608366. J Med Chem. 1997. PMID: 9171877

3

Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Mong S, Keller KM, Brock T, Kogan TP, Dixon RA. Wu C, et al. Among authors: okun i. J Med Chem. 1997 May 23;40(11):1690-7. doi: 10.1021/jm9700068. J Med Chem. 1997. PMID: 9171878

4

The discovery and structure-activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET(B) receptor.

Chan MF, Kois A, Verner EJ, Raju BG, Castillo RS, Wu C, Okun I, Stavros FD, Balaji VN. Chan MF, et al. Among authors: okun i. Bioorg Med Chem. 1998 Dec;6(12):2301-16. doi: 10.1016/s0968-0896(98)80010-2. Bioorg Med Chem. 1998. PMID: 9925292

5

Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening.

Chan MF, Okun I, Stavros FL, Hwang E, Wolff ME, Balaji VN. Chan MF, et al. Among authors: okun i. Biochem Biophys Res Commun. 1994 May 30;201(1):228-34. doi: 10.1006/bbrc.1994.1693. Biochem Biophys Res Commun. 1994. PMID: 8198578

6

Serotonin antagonist profiling on 5HT2A and 5HT2C receptors by nonequilibrium intracellular calcium response using an automated flow-through fluorescence analysis system, HT-PS 100.

Kaler G, Otto M, Okun A, Okun I. Kaler G, et al. Among authors: okun a, okun i. J Biomol Screen. 2002 Jun;7(3):291-301. doi: 10.1177/108705710200700313. J Biomol Screen. 2002. PMID: 12097192

7

Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

Ivachtchenko AV, Frolov EB, Mitkin OD, Kysil VM, Khvat AV, Okun IM, Tkachenko SE. Ivachtchenko AV, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3183-7. doi: 10.1016/j.bmcl.2009.04.128. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19443217

8

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM. Ivachtchenko AV, et al. Among authors: okun im. J Med Chem. 2011 Dec 8;54(23):8161-73. doi: 10.1021/jm201079g. Epub 2011 Nov 10. J Med Chem. 2011. PMID: 22029285

9

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM. Ivachtchenko AV, et al. Eur J Med Chem. 2010 Feb;45(2):782-9. doi: 10.1016/j.ejmech.2009.10.035. Epub 2009 Oct 31. Eur J Med Chem. 2010. PMID: 19939513

10

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun I. Ivachtchenko AV, et al. Among authors: okun i. Bioorg Med Chem. 2011 Feb 15;19(4):1482-91. doi: 10.1016/j.bmc.2010.12.055. Epub 2011 Jan 5. Bioorg Med Chem. 2011. PMID: 21277782

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