Crystal RG - Search Results

1

Gene transfer to freshly isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA.

Rosenfeld MA, Chu CS, Seth P, Danel C, Banks T, Yoneyama K, Yoshimura K, Crystal RG. Rosenfeld MA, et al. Among authors: crystal rg. Hum Gene Ther. 1994 Mar;5(3):331-42. doi: 10.1089/hum.1994.5.3-331. Hum Gene Ther. 1994. PMID: 7517189

2

Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis.

Trapnell BC, Chu CS, Paakko PK, Banks TC, Yoshimura K, Ferrans VJ, Chernick MS, Crystal RG. Trapnell BC, et al. Among authors: crystal rg. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6565-9. doi: 10.1073/pnas.88.15.6565. Proc Natl Acad Sci U S A. 1991. PMID: 1713683 Free PMC article.

3

Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin.

Yoshimura K, Nakamura H, Trapnell BC, Chu CS, Dalemans W, Pavirani A, Lecocq JP, Crystal RG. Yoshimura K, et al. Among authors: crystal rg. Nucleic Acids Res. 1991 Oct 11;19(19):5417-23. doi: 10.1093/nar/19.19.5417. Nucleic Acids Res. 1991. PMID: 1717947 Free PMC article.

4

Transfer of a constitutive viral promoter-cystic fibrosis transmembrane conductance regulator cDNA to human epithelial cells conveys resistance to down-regulation of cAMP-regulated Cl- secretion in the presence of inflammatory stimuli.

Kobayashi N, Rosenthal ER, Yoshimura K, Crystal RG. Kobayashi N, et al. Among authors: crystal rg. Nucleic Acids Res. 1994 Oct 25;22(21):4470-6. doi: 10.1093/nar/22.21.4470. Nucleic Acids Res. 1994. PMID: 7526342 Free PMC article.

5

Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.

Brody SL, Metzger M, Danel C, Rosenfeld MA, Crystal RG. Brody SL, et al. Among authors: crystal rg. Hum Gene Ther. 1994 Jul;5(7):821-36. doi: 10.1089/hum.1994.5.7-821. Hum Gene Ther. 1994. PMID: 7526901

6

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.

Crystal RG, McElvaney NG, Rosenfeld MA, Chu CS, Mastrangeli A, Hay JG, Brody SL, Jaffe HA, Eissa NT, Danel C. Crystal RG, et al. Nat Genet. 1994 Sep;8(1):42-51. doi: 10.1038/ng0994-42. Nat Genet. 1994. PMID: 7527271 Clinical Trial.

7

Increasing expression of the normal human CFTR cDNA in cystic fibrosis epithelial cells results in a progressive increase in the level of CFTR protein expression, but a limit on the level of cAMP-stimulated chloride secretion.

Rosenfeld MA, Rosenfeld SJ, Danel C, Banks TC, Crystal RG. Rosenfeld MA, et al. Among authors: crystal rg. Hum Gene Ther. 1994 Sep;5(9):1121-9. doi: 10.1089/hum.1994.5.9-1121. Hum Gene Ther. 1994. PMID: 7530494

8

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung.

Crystal RG, Jaffe A, Brody S, Mastrangeli A, McElvaney NG, Rosenfeld M, Chu CS, Danel C, Hay J, Eissa T. Crystal RG, et al. Hum Gene Ther. 1995 May;6(5):643-66. doi: 10.1089/hum.1995.6.5-643. Hum Gene Ther. 1995. PMID: 7578401 No abstract available.

9

Alternative splicing of intron 23 of the human cystic fibrosis transmembrane conductance regulator gene resulting in a novel exon and transcript coding for a shortened intracytoplasmic C terminus.

Yoshimura K, Chu CS, Crystal RG. Yoshimura K, et al. Among authors: crystal rg. J Biol Chem. 1993 Jan 5;268(1):686-90. J Biol Chem. 1993. PMID: 7678008 Free article.

10

Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA.

Chu CS, Trapnell BC, Curristin S, Cutting GR, Crystal RG. Chu CS, et al. Among authors: crystal rg. Nat Genet. 1993 Feb;3(2):151-6. doi: 10.1038/ng0293-151. Nat Genet. 1993. PMID: 7684646

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