Stahlhut M - Search Results

1

Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs.

Carroll SS, Stahlhut M, Geib J, Olsen DB. Carroll SS, et al. Among authors: stahlhut m. J Biol Chem. 1994 Dec 23;269(51):32351-7. J Biol Chem. 1994. PMID: 7528214 Free article.

2

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.

Carroll SS, Tomassini JE, Bosserman M, Getty K, Stahlhut MW, Eldrup AB, Bhat B, Hall D, Simcoe AL, LaFemina R, Rutkowski CA, Wolanski B, Yang Z, Migliaccio G, De Francesco R, Kuo LC, MacCoss M, Olsen DB. Carroll SS, et al. Among authors: stahlhut mw. J Biol Chem. 2003 Apr 4;278(14):11979-84. doi: 10.1074/jbc.M210914200. Epub 2003 Jan 27. J Biol Chem. 2003. PMID: 12554735 Free article.

3

Elucidation of basic mechanistic and kinetic properties of influenza endonuclease using chemically synthesized RNAs.

Olsen DB, Benseler F, Cole JL, Stahlhut MW, Dempski RE, Darke PL, Kuo LC. Olsen DB, et al. Among authors: stahlhut mw. J Biol Chem. 1996 Mar 29;271(13):7435-9. doi: 10.1074/jbc.271.13.7435. J Biol Chem. 1996. PMID: 8631770 Free article.

4

Expression and purification of retroviral HIV-1 reverse transcriptase.

Stahlhut MW, Olsen DB. Stahlhut MW, et al. Methods Enzymol. 1996;275:122-33. doi: 10.1016/s0076-6879(96)75010-3. Methods Enzymol. 1996. PMID: 9026635

5

Non-active site changes elicit broad-based cross-resistance of the HIV-1 protease to inhibitors.

Olsen DB, Stahlhut MW, Rutkowski CA, Schock HB, vanOlden AL, Kuo LC. Olsen DB, et al. Among authors: stahlhut mw. J Biol Chem. 1999 Aug 20;274(34):23699-701. doi: 10.1074/jbc.274.34.23699. J Biol Chem. 1999. PMID: 10446127 Free article.

6

Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.

Carroll SS, Geib J, Olsen DB, Stahlhut M, Shafer JA, Kuo LC. Carroll SS, et al. Among authors: stahlhut m. Biochemistry. 1994 Mar 1;33(8):2113-20. doi: 10.1021/bi00174a018. Biochemistry. 1994. PMID: 7509634

7

Purification and characterization of HIV-1 reverse transcriptase having a 1:1 ratio of p66 and p51 subunits.

Stahlhut M, Li Y, Condra JH, Fu J, Gotlib L, Graham DJ, Olsen DB. Stahlhut M, et al. Protein Expr Purif. 1994 Dec;5(6):614-21. doi: 10.1006/prep.1994.1084. Protein Expr Purif. 1994. PMID: 7532052

8

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.

Olsen DB, Eldrup AB, Bartholomew L, Bhat B, Bosserman MR, Ceccacci A, Colwell LF, Fay JF, Flores OA, Getty KL, Grobler JA, LaFemina RL, Markel EJ, Migliaccio G, Prhavc M, Stahlhut MW, Tomassini JE, MacCoss M, Hazuda DJ, Carroll SS. Olsen DB, et al. Among authors: stahlhut mw. Antimicrob Agents Chemother. 2004 Oct;48(10):3944-53. doi: 10.1128/AAC.48.10.3944-3953.2004. Antimicrob Agents Chemother. 2004. PMID: 15388457 Free PMC article.

9

Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.

McCauley JA, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, Gilbert KF, Bush KJ, Holloway MK, Swestock J, Wan BL, Carroll SS, DiMuzio JM, Graham DJ, Ludmerer SW, Mao SS, Stahlhut MW, Fandozzi CM, Trainor N, Olsen DB, Vacca JP, Liverton NJ. McCauley JA, et al. Among authors: stahlhut mw. J Med Chem. 2010 Mar 25;53(6):2443-63. doi: 10.1021/jm9015526. J Med Chem. 2010. PMID: 20163176

10

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.

Duffy JL, Kirk BA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: stahlhut m. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3323-6. doi: 10.1016/s0960-894x(03)00680-2. Bioorg Med Chem Lett. 2003. PMID: 12951118

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