Roughley PJ - Search Results

1

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS. Hughes CE, et al. Among authors: roughley pj. Biochem J. 1995 Feb 1;305 ( Pt 3)(Pt 3):799-804. doi: 10.1042/bj3050799. Biochem J. 1995. PMID: 7531436 Free PMC article.

2

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.

Sztrolovics R, White RJ, Roughley PJ, Mort JS. Sztrolovics R, et al. Among authors: roughley pj. Biochem J. 2002 Mar 1;362(Pt 2):465-72. doi: 10.1042/0264-6021:3620465. Biochem J. 2002. PMID: 11853556 Free PMC article.

3

Variations in aggrecan structure modulate its susceptibility to aggrecanases.

Roughley PJ, Barnett J, Zuo F, Mort JS. Roughley PJ, et al. Biochem J. 2003 Oct 1;375(Pt 1):183-9. doi: 10.1042/BJ20030609. Biochem J. 2003. PMID: 12859252 Free PMC article.

4

Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ.

Nguyen Q, Murphy G, Roughley PJ, Mort JS. Nguyen Q, et al. Among authors: roughley pj. Biochem J. 1989 Apr 1;259(1):61-7. doi: 10.1042/bj2590061. Biochem J. 1989. PMID: 2719651 Free PMC article.

5

The action of human articular-cartilage metalloproteinase on proteoglycan and link protein. Similarities between products of degradation in situ and in vitro.

Campbell IK, Roughley PJ, Mort JS. Campbell IK, et al. Among authors: roughley pj. Biochem J. 1986 Jul 1;237(1):117-22. doi: 10.1042/bj2370117. Biochem J. 1986. PMID: 3541894 Free PMC article.

6

Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.

Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ. Nguyen Q, et al. Among authors: roughley pj. Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):595-8. doi: 10.1042/bj2950595. Biochem J. 1993. PMID: 7694569 Free PMC article.

7

Aggrecan degradation in human intervertebral disc and articular cartilage.

Sztrolovics R, Alini M, Roughley PJ, Mort JS. Sztrolovics R, et al. Among authors: roughley pj. Biochem J. 1997 Aug 15;326 ( Pt 1)(Pt 1):235-41. doi: 10.1042/bj3260235. Biochem J. 1997. PMID: 9337874 Free PMC article.

8

Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.

Sztrolovics R, White RJ, Poole AR, Mort JS, Roughley PJ. Sztrolovics R, et al. Among authors: roughley pj. Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):571-7. Biochem J. 1999. PMID: 10215595 Free PMC article.

9

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B. Little CB, et al. Among authors: roughley pj. Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):61-8. Biochem J. 1999. PMID: 10548534 Free PMC article.

10

Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.

Hughes CE, Caterson B, White RJ, Roughley PJ, Mort JS. Hughes CE, et al. Among authors: roughley pj. J Biol Chem. 1992 Aug 15;267(23):16011-4. J Biol Chem. 1992. PMID: 1379586 Free article.

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