Schulte TW - Search Results

1

Taxol induction of p21WAF1 and p53 requires c-raf-1.

Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L. Blagosklonny MV, et al. Among authors: schulte tw. Cancer Res. 1995 Oct 15;55(20):4623-6. Cancer Res. 1995. PMID: 7553639

2

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

Blagosklonny MV, Schulte T, Nguyen P, Trepel J, Neckers LM. Blagosklonny MV, et al. Cancer Res. 1996 Apr 15;56(8):1851-4. Cancer Res. 1996. PMID: 8620503

3

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.

Schulte TW, Blagosklonny MV, Ingui C, Neckers L. Schulte TW, et al. J Biol Chem. 1995 Oct 13;270(41):24585-8. doi: 10.1074/jbc.270.41.24585. J Biol Chem. 1995. PMID: 7592678 Free article.

4

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

Schulte TW, Blagosklonny MV, Romanova L, Mushinski JF, Monia BP, Johnston JF, Nguyen P, Trepel J, Neckers LM. Schulte TW, et al. Mol Cell Biol. 1996 Oct;16(10):5839-45. doi: 10.1128/MCB.16.10.5839. Mol Cell Biol. 1996. PMID: 8816498 Free PMC article.

5

Geldanamycin-induced destabilization of Raf-1 involves the proteasome.

Schulte TW, An WG, Neckers LM. Schulte TW, et al. Biochem Biophys Res Commun. 1997 Oct 29;239(3):655-9. doi: 10.1006/bbrc.1997.7527. Biochem Biophys Res Commun. 1997. PMID: 9367823

6

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.

Schulte TW, Neckers LM. Schulte TW, et al. Cancer Chemother Pharmacol. 1998;42(4):273-9. doi: 10.1007/s002800050817. Cancer Chemother Pharmacol. 1998. PMID: 9744771

7

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins.

Marcu MG, Schulte TW, Neckers L. Marcu MG, et al. Among authors: schulte tw. J Natl Cancer Inst. 2000 Feb 2;92(3):242-8. doi: 10.1093/jnci/92.3.242. J Natl Cancer Inst. 2000. PMID: 10655441

8

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome.

An WG, Schulte TW, Neckers LM. An WG, et al. Among authors: schulte tw. Cell Growth Differ. 2000 Jul;11(7):355-60. Cell Growth Differ. 2000. PMID: 10939589

9

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.

Ochel HJ, Schulte TW, Nguyen P, Trepel J, Neckers L. Ochel HJ, et al. Among authors: schulte tw. Mol Genet Metab. 1999 Jan;66(1):24-30. doi: 10.1006/mgme.1998.2774. Mol Genet Metab. 1999. PMID: 9973544

10

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K, Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T, Akinaga S. Soga S, et al. Among authors: schulte tw. Cancer Res. 1999 Jun 15;59(12):2931-8. Cancer Res. 1999. PMID: 10383157

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