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Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.
Lewis W, Levine ES, Griniuviene B, Tankersley KO, Colacino JM, Sommadossi JP, Watanabe KA, Perrino FW. Lewis W, et al. Among authors: griniuviene b. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7. doi: 10.1073/pnas.93.8.3592. Proc Natl Acad Sci U S A. 1996. PMID: 8622980 Free PMC article.
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