Chang LL - Search Results

1

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Kivlighn SD, Siegl PK, Lotti VJ, Chang RS, et al. Chang LL, et al. Among authors: chang rs. J Med Chem. 1995 Sep 15;38(19):3741-58. doi: 10.1021/jm00019a004. J Med Chem. 1995. PMID: 7562905

2

In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.

Gabel RA, Kivlighn SD, Zingaro GJ, Schorn TW, Schaffer LW, Ashton WT, Chang LL, Flanagan K, Greenlee WJ, Siegl PK. Gabel RA, et al. Among authors: chang ll. Clin Exp Hypertens. 1995 Aug;17(6):931-53. doi: 10.3109/10641969509033644. Clin Exp Hypertens. 1995. PMID: 7581262 Free article.

3

Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Siegl PK, Kivlighn SD, Lotti VJ, Chang RS, et al. Chang LL, et al. Among authors: chang rs. J Med Chem. 1994 Dec 23;37(26):4464-78. doi: 10.1021/jm00052a006. J Med Chem. 1994. PMID: 7799397

4

Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.

Ashton WT, Chang LL, Flanagan KL, Hutchins SM, Naylor EM, Chakravarty PK, Patchett AA, Greenlee WJ, Chen TB, Faust KA, et al. Ashton WT, et al. Among authors: chang ll. J Med Chem. 1994 Aug 19;37(17):2808-24. doi: 10.1021/jm00043a020. J Med Chem. 1994. PMID: 8064808

5

Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones.

Chang LL, Ashton WT, Flanagan KL, Strelitz RA, MacCoss M, Greenlee WJ, Chang RS, Lotti VJ, Faust KA, Chen TB, et al. Chang LL, et al. Among authors: chang rs. J Med Chem. 1993 Aug 20;36(17):2558-68. doi: 10.1021/jm00069a015. J Med Chem. 1993. PMID: 8355255

6

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.

Ashton WT, Cantone CL, Chang LL, Hutchins SM, Strelitz RA, MacCoss M, Chang RS, Lotti VJ, Faust KA, Chen TB, et al. Ashton WT, et al. Among authors: chang rs, chang ll. J Med Chem. 1993 Mar 5;36(5):591-609. doi: 10.1021/jm00057a009. J Med Chem. 1993. PMID: 8496939

7

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Jiang J, Lin P, Hoang M, Chang L, Tan C, Feighner S, Palyha OC, Hreniuk DL, Pan J, Sailer AW, Morin NR, MacNeil DJ, Howard AD, Van der Ploeg LH, Goulet MT, DeVita RJ. Jiang J, et al. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5275-9. doi: 10.1016/j.bmcl.2006.08.008. Epub 2006 Aug 17. Bioorg Med Chem Lett. 2006. PMID: 16919453

8

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine.

Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, Burns HD, Hargreaves RJ, Mills SG. Lin P, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5191-8. doi: 10.1016/j.bmcl.2007.06.085. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17637506

9

Substituted imidazoles as glucagon receptor antagonists.

Chang LL, Sidler KL, Cascieri MA, de Laszlo S, Koch G, Li B, MacCoss M, Mantlo N, O'Keefe S, Pang M, Rolando A, Hagmann WK. Chang LL, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2549-53. doi: 10.1016/s0960-894x(01)00498-x. Bioorg Med Chem Lett. 2001. PMID: 11549467

10

The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.

Hagmann WK, Durette PL, Lanza T, Kevin NJ, de Laszlo SE, Kopka IE, Young D, Magriotis PA, Li B, Lin LS, Yang G, Kamenecka T, Chang LL, Wilson J, MacCoss M, Mills SG, Van Riper G, McCauley E, Egger LA, Kidambi U, Lyons K, Vincent S, Stearns R, Colletti A, Teffera J, Tong S, Fenyk-Melody J, Owens K, Levorse D, Kim P, Schmidt JA, Mumford RA. Hagmann WK, et al. Among authors: chang ll. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2709-13. doi: 10.1016/s0960-894x(01)00544-3. Bioorg Med Chem Lett. 2001. PMID: 11591507

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