Wright JN - Search Results

1

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase).

Lee-Robichaud P, Shyadehi AZ, Wright JN, Akhtar ME, Akhtar M. Lee-Robichaud P, et al. Among authors: wright jn. Biochemistry. 1995 Oct 31;34(43):14104-13. doi: 10.1021/bi00043a015. Biochemistry. 1995. PMID: 7578007

2

A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17).

Akhtar M, Wright JN, Lee-Robichaud P. Akhtar M, et al. Among authors: wright jn. J Steroid Biochem Mol Biol. 2011 May;125(1-2):2-12. doi: 10.1016/j.jsbmb.2010.11.003. Epub 2010 Nov 19. J Steroid Biochem Mol Biol. 2011. PMID: 21094255 Review.

3

Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: studies on cytochrome P-450(17)alpha.

Akhtar M, Corina D, Miller S, Shyadehi AZ, Wright JN. Akhtar M, et al. Among authors: wright jn. Biochemistry. 1994 Apr 12;33(14):4410-8. doi: 10.1021/bi00180a039. Biochemistry. 1994. PMID: 8155659

4

Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes.

Akhtar M, Njar VC, Wright JN. Akhtar M, et al. Among authors: wright jn. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):375-87. doi: 10.1016/0960-0760(93)90241-n. J Steroid Biochem Mol Biol. 1993. PMID: 8476751 Review.

5

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51).

Shyadehi AZ, Lamb DC, Kelly SL, Kelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. Shyadehi AZ, et al. Among authors: wright jn. J Biol Chem. 1996 May 24;271(21):12445-50. doi: 10.1074/jbc.271.21.12445. J Biol Chem. 1996. PMID: 8647850 Free article.

6

Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications.

Lee-Robichaud P, Wright JN, Akhtar ME, Akhtar M. Lee-Robichaud P, et al. Among authors: wright jn. Biochem J. 1995 Jun 15;308 ( Pt 3)(Pt 3):901-8. doi: 10.1042/bj3080901. Biochem J. 1995. PMID: 8948449 Free PMC article.

7

Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.

Lee-Robichaud P, Kaderbhai MA, Kaderbhai N, Wright JN, Akhtar M. Lee-Robichaud P, et al. Among authors: wright jn. Biochem J. 1997 Feb 1;321 ( Pt 3)(Pt 3):857-63. doi: 10.1042/bj3210857. Biochem J. 1997. PMID: 9032476 Free PMC article.

8

The impact of aromatase mechanism on other P450s.

Akhtar M, Lee-Robichaud P, Akhtar ME, Wright JN. Akhtar M, et al. Among authors: wright jn. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):127-32. J Steroid Biochem Mol Biol. 1997. PMID: 9365181

9

The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities.

Lee-Robichaud P, Akhtar ME, Wright JN, Sheikh QI, Akhtar M. Lee-Robichaud P, et al. Among authors: wright jn. J Steroid Biochem Mol Biol. 2004 Oct;92(3):119-30. doi: 10.1016/j.jsbmb.2004.07.005. J Steroid Biochem Mol Biol. 2004. PMID: 15555906

10

A review of ¹⁸O labelling Studies to probe the mechanism of aromatase (CYP191A).

Akhtar M, Wright JN. Akhtar M, et al. Among authors: wright jn. J Steroid Biochem Mol Biol. 2022 Feb;216:106010. doi: 10.1016/j.jsbmb.2021.106010. Epub 2021 Oct 30. J Steroid Biochem Mol Biol. 2022. PMID: 34757095 Review.

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