Cai H - Search Results

1

CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit.

Boger DL, Yun W, Cai H, Han N. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1995 Jun;3(6):761-7. doi: 10.1016/0968-0896(95)00066-p. Bioorg Med Chem. 1995. PMID: 7582954

2

Synthesis and evaluation of deglycobleomycin A2 analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: direct functional characterization of the requirement for secondary amide metal complexation.

Boger DL, Teramoto S, Cai H. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1996 Feb;4(2):179-93. doi: 10.1016/0968-0896(95)00183-2. Bioorg Med Chem. 1996. PMID: 8814877

3

Synthesis and evaluation of potential N pi and N sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A2: functional characterization of imidazole N pi metal complexation.

Boger DL, Ramsey TM, Cai H. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1996 Feb;4(2):195-207. doi: 10.1016/0968-0896(95)00184-0. Bioorg Med Chem. 1996. PMID: 8814878

4

Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: noncovalent binding coincidental with alkylation.

Boger DL, Zhou J, Cai H. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1996 Jun;4(6):859-67. doi: 10.1016/0968-0896(96)00073-9. Bioorg Med Chem. 1996. PMID: 8818235

5

N-methyl threonine analogues of deglycobleomycin A2: synthesis and evaluation.

Boger DL, Teramoto S, Cai H. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1997 Aug;5(8):1577-89. doi: 10.1016/s0968-0896(97)00107-7. Bioorg Med Chem. 1997. PMID: 9313863

6

Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.

Boger DL, Kochanny MJ, Cai H, Wyatt D, Kitos PA, Warren MS, Ramcharan J, Gooljarsingh LT, Benkovic SJ. Boger DL, et al. Among authors: cai h. Bioorg Med Chem. 1998 Jun;6(6):643-59. doi: 10.1016/s0968-0896(98)00040-6. Bioorg Med Chem. 1998. PMID: 9681131 No abstract available.

7

Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivity.

Boger DL, McKie JA, Cai H, Cacciari B, Baraldi PG. Boger DL, et al. Among authors: cai h. J Org Chem. 1996 Mar 8;61(5):1710-1729. doi: 10.1021/jo952033g. J Org Chem. 1996. PMID: 11667041

8

Bleomycin: Synthetic and Mechanistic Studies.

Boger DL, Cai H. Boger DL, et al. Among authors: cai h. Angew Chem Int Ed Engl. 1999 Feb 15;38(4):448-476. doi: 10.1002/(SICI)1521-3773(19990215)38:4<448::AID-ANIE448>3.0.CO;2-W. Angew Chem Int Ed Engl. 1999. PMID: 29711767 Review.

9

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.

Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Among authors: cai h. Biochemistry. 2001 Nov 13;40(45):13538-47. doi: 10.1021/bi011482+. Biochemistry. 2001. PMID: 11695901

10

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.

Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Among authors: cai h. Biochemistry. 1999 Dec 21;38(51):16783-93. doi: 10.1021/bi991888a. Biochemistry. 1999. PMID: 10606510

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