Hamilton AD - Search Results

1

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.

2

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.

Kauffmann RC, Qian Y, Vogt A, Sebti SM, Hamilton AD, Carthew RW. Kauffmann RC, et al. Among authors: hamilton ad. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10919-23. doi: 10.1073/pnas.92.24.10919. Proc Natl Acad Sci U S A. 1995. PMID: 7479910 Free PMC article.

3

Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.

Vogt A, Sun J, Qian Y, Tan-Chiu E, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: hamilton ad. Biochemistry. 1995 Sep 26;34(38):12398-403. doi: 10.1021/bi00038a037. Biochemistry. 1995. PMID: 7547984

4

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.

Lerner EC, Qian Y, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26770-3. doi: 10.1074/jbc.270.45.26770. J Biol Chem. 1995. PMID: 7592913 Free article.

5

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.

McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD, et al. McGuire TF, et al. Among authors: hamilton ad. Biochem Biophys Res Commun. 1995 Sep 5;214(1):295-303. doi: 10.1006/bbrc.1995.2287. Biochem Biophys Res Commun. 1995. PMID: 7669049

6

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

Sun J, Qian Y, Hamilton AD, Sebti SM. Sun J, et al. Among authors: hamilton ad. Cancer Res. 1995 Oct 1;55(19):4243-7. Cancer Res. 1995. PMID: 7671229

7

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.

Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: hamilton ad. J Biol Chem. 1995 Jan 13;270(2):660-4. doi: 10.1074/jbc.270.2.660. J Biol Chem. 1995. PMID: 7822292 Free article.

8

Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.

Qian Y, Blaskovich MA, Saleem M, Seong CM, Wathen SP, Hamilton AD, Sebti SM. Qian Y, et al. Among authors: hamilton ad. J Biol Chem. 1994 Apr 29;269(17):12410-3. J Biol Chem. 1994. PMID: 8175645 Free article.

9

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.

Nigam M, Seong CM, Qian Y, Hamilton AD, Sebti SM. Nigam M, et al. Among authors: hamilton ad. J Biol Chem. 1993 Oct 5;268(28):20695-8. J Biol Chem. 1993. PMID: 8407887 Free article.

10

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.

Qian Y, Vogt A, Sebti SM, Hamilton AD. Qian Y, et al. Among authors: hamilton ad. J Med Chem. 1996 Jan 5;39(1):217-23. doi: 10.1021/jm950414g. J Med Chem. 1996. PMID: 8568811

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