Sun J - Search Results

1

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: sun j. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.

2

Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.

Vogt A, Sun J, Qian Y, Tan-Chiu E, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: sun j. Biochemistry. 1995 Sep 26;34(38):12398-403. doi: 10.1021/bi00038a037. Biochemistry. 1995. PMID: 7547984

3

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.

McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD, et al. McGuire TF, et al. Among authors: sun j. Biochem Biophys Res Commun. 1995 Sep 5;214(1):295-303. doi: 10.1006/bbrc.1995.2287. Biochem Biophys Res Commun. 1995. PMID: 7669049

4

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

Sun J, Qian Y, Hamilton AD, Sebti SM. Sun J, et al. Cancer Res. 1995 Oct 1;55(19):4243-7. Cancer Res. 1995. PMID: 7671229

5

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.

Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: sun j. J Biol Chem. 1997 Oct 24;272(43):27224-9. doi: 10.1074/jbc.272.43.27224. J Biol Chem. 1997. PMID: 9341167 Free article.

6

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.

Sun J, Qian Y, Chen Z, Marfurt J, Hamilton AD, Sebti SM. Sun J, et al. J Biol Chem. 1999 Mar 12;274(11):6930-4. doi: 10.1074/jbc.274.11.6930. J Biol Chem. 1999. PMID: 10066746 Free article.

7

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

Miquel K, Pradines A, Sun J, Qian Y, Hamilton AD, Sebti SM, Favre G. Miquel K, et al. Among authors: sun j. Cancer Res. 1997 May 15;57(10):1846-50. Cancer Res. 1997. PMID: 9157972

8

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.

Sun J, Qian Y, Hamilton AD, Sebti SM. Sun J, et al. Oncogene. 1998 Mar;16(11):1467-73. doi: 10.1038/sj.onc.1201656. Oncogene. 1998. PMID: 9525745

9

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26. Cancer Res. 1999. PMID: 10519405

10

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice.

Chen Z, Sun J, Pradines A, Favre G, Adnane J, Sebti SM. Chen Z, et al. Among authors: sun j. J Biol Chem. 2000 Jun 16;275(24):17974-8. doi: 10.1074/jbc.C000145200. J Biol Chem. 2000. PMID: 10770919 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

45,594 results

Search Page

Filters