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72 results

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Page 1
A paradigm for drug discovery employing encoded combinatorial libraries.
Burbaum JJ, Ohlmeyer MH, Reader JC, Henderson I, Dillard LW, Li G, Randle TL, Sigal NH, Chelsky D, Baldwin JJ. Burbaum JJ, et al. Among authors: sigal nh. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6027-31. doi: 10.1073/pnas.92.13.6027. Proc Natl Acad Sci U S A. 1995. PMID: 7597074 Free PMC article.
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.
McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ. McMillan K, et al. Among authors: sigal nh. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1506-11. doi: 10.1073/pnas.97.4.1506. Proc Natl Acad Sci U S A. 2000. PMID: 10677491 Free PMC article.
Surfing the piperazine core of tricyclic farnesyltransferase inhibitors.
Rokosz LL, Huang CY, Reader JC, Stauffer TM, Chelsky D, Sigal NH, Ganguly AK, Baldwin JJ. Rokosz LL, et al. Among authors: sigal nh. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5537-43. doi: 10.1016/j.bmcl.2005.08.074. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202593
New technologies for high-throughput screening.
Burbaum JJ, Sigal NH. Burbaum JJ, et al. Among authors: sigal nh. Curr Opin Chem Biol. 1997 Jun;1(1):72-8. doi: 10.1016/s1367-5931(97)80111-1. Curr Opin Chem Biol. 1997. PMID: 9667842 Review.
Small molecule antagonists of the bradykinin B1 receptor.
Horlick RA, Ohlmeyer MH, Stroke IL, Strohl B, Pan G, Schilling AE, Paradkar V, Quintero JG, You M, Riviello C, Thorn MB, Damaj B, Fitzpatrick VD, Dolle RE, Webb ML, Baldwin JJ, Sigal NH. Horlick RA, et al. Among authors: sigal nh. Immunopharmacology. 1999 Sep;43(2-3):169-77. doi: 10.1016/s0162-3109(99)00130-7. Immunopharmacology. 1999. PMID: 10596850
A tacrolimus-related immunosuppressant with reduced toxicity.
Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, DaSilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J, Singer I, Sigal NH, Williamson AR, Parsons WH, Wyvratt M. Dumont FJ, et al. Among authors: sigal nh. Transplantation. 1998 Jan 15;65(1):18-26. doi: 10.1097/00007890-199801150-00005. Transplantation. 1998. PMID: 9448138
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.
Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W. Koo GC, et al. Among authors: sigal nh. J Immunol. 1997 Jun 1;158(11):5120-8. J Immunol. 1997. PMID: 9164927
FK-506--a novel immunosuppressant.
Parsons WH, Sigal NH, Wyvratt MJ. Parsons WH, et al. Among authors: sigal nh. Ann N Y Acad Sci. 1993 Jun 23;685:22-36. doi: 10.1111/j.1749-6632.1993.tb35847.x. Ann N Y Acad Sci. 1993. PMID: 7689805 Review. No abstract available.
72 results