Shima F - Search Results

1

Autophosphorylation of insulin receptor in a patient with Werner's syndrome associated with insulin resistant diabetes mellitus.

Shima F, Ishida Y, Hotta K, Hagino H, Hozumi T, Shii K, Baba S, Kazumi T. Shima F, et al. Endocr J. 1995 Feb;42(1):107-13. doi: 10.1507/endocrj.42.107. Endocr J. 1995. PMID: 7599691 Free article.

2

Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.

Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F. Matsumoto S, et al. Among authors: shima f. Sci Rep. 2016 May 16;6:25931. doi: 10.1038/srep25931. Sci Rep. 2016. PMID: 27180801 Free PMC article.

3

Structural basis for conformational dynamics of GTP-bound Ras protein.

Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Shima F, et al. J Biol Chem. 2010 Jul 16;285(29):22696-705. doi: 10.1074/jbc.M110.125161. Epub 2010 May 17. J Biol Chem. 2010. PMID: 20479006 Free PMC article.

4

Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.

Matsumoto K, Shima F, Muraoka S, Araki M, Hu L, Ijiri Y, Hirai R, Liao J, Yoshioka T, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Matsumoto K, et al. Among authors: shima f. J Biol Chem. 2011 Apr 29;286(17):15403-12. doi: 10.1074/jbc.M110.204933. Epub 2011 Mar 9. J Biol Chem. 2011. PMID: 21388959 Free PMC article.

5

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants.

Muraoka S, Shima F, Araki M, Inoue T, Yoshimoto A, Ijiri Y, Seki N, Tamura A, Kumasaka T, Yamamoto M, Kataoka T. Muraoka S, et al. Among authors: shima f. FEBS Lett. 2012 Jun 12;586(12):1715-8. doi: 10.1016/j.febslet.2012.04.058. Epub 2012 May 11. FEBS Lett. 2012. PMID: 22584058 Free article.

6

Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction.

Shima F, Yoshikawa Y, Matsumoto S, Kataoka T. Shima F, et al. Enzymes. 2013;34 Pt. B:1-23. doi: 10.1016/B978-0-12-420146-0.00001-9. Epub 2013 Nov 7. Enzymes. 2013. PMID: 25034098 Review.

7

Current status of the development of Ras inhibitors.

Shima F, Matsumoto S, Yoshikawa Y, Kawamura T, Isa M, Kataoka T. Shima F, et al. J Biochem. 2015 Aug;158(2):91-9. doi: 10.1093/jb/mvv060. Epub 2015 Jun 22. J Biochem. 2015. PMID: 26100833 Review.

8

Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy.

Matsunaga S, Hano Y, Saito Y, Fujimoto KJ, Kumasaka T, Matsumoto S, Kataoka T, Shima F, Tanaka S. Matsunaga S, et al. Among authors: shima f. J Mol Graph Model. 2017 Oct;77:51-63. doi: 10.1016/j.jmgm.2017.07.028. Epub 2017 Jul 29. J Mol Graph Model. 2017. PMID: 28837923

9

Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein.

Matsumoto S, Taniguchi-Tamura H, Araki M, Kawamura T, Miyamoto R, Tsuda C, Shima F, Kumasaka T, Okuno Y, Kataoka T. Matsumoto S, et al. Among authors: shima f. Biochem Biophys Res Commun. 2021 Aug 6;565:85-90. doi: 10.1016/j.bbrc.2021.05.084. Epub 2021 Jun 5. Biochem Biophys Res Commun. 2021. PMID: 34102474

10

Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.

Ye M, Shima F, Muraoka S, Liao J, Okamoto H, Yamamoto M, Tamura A, Yagi N, Ueki T, Kataoka T. Ye M, et al. Among authors: shima f. J Biol Chem. 2005 Sep 2;280(35):31267-75. doi: 10.1074/jbc.M505503200. Epub 2005 Jun 30. J Biol Chem. 2005. PMID: 15994326 Free article.

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