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Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
Rosini M, Bixel MG, Marucci G, Budriesi R, Krauss M, Bolognesi ML, Minarini A, Tumiatti V, Hucho F, Melchiorre C. Rosini M, et al. Among authors: melchiorre c. J Med Chem. 2002 Apr 25;45(9):1860-78. doi: 10.1021/jm011067f. J Med Chem. 2002. PMID: 11960498
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines.
Minarini A, Bolognesi ML, Budriesi R, Canossa M, Chiarini A, Spampinato S, Melchiorre C. Minarini A, et al. Among authors: melchiorre c. J Med Chem. 1994 Sep 30;37(20):3363-72. doi: 10.1021/jm00046a021. J Med Chem. 1994. PMID: 7932564
Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.
Melchiorre C, Bolognesi ML, Chiarini A, Minarini A, Spampinato S. Melchiorre C, et al. J Med Chem. 1993 Nov 12;36(23):3734-7. doi: 10.1021/jm00075a032. J Med Chem. 1993. PMID: 8246244 No abstract available.
173 results