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Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein.
Zhang WJ, Ohnishi K, Yoshida H, Pan L, Maksumova L, Muratkhodjaev F, Luo JM, Shigeno K, Fujisawa S, Naito K, Nakamura S, Shinjo K, Takeshita A, Ohno R. Zhang WJ, et al. Among authors: shinjo k. Jpn J Cancer Res. 2000 Jun;91(6):604-11. doi: 10.1111/j.1349-7006.2000.tb00988.x. Jpn J Cancer Res. 2000. PMID: 10874212 Free PMC article.
Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines.
Naito K, Takeshita A, Shigeno K, Nakamura S, Fujisawa S, Shinjo K, Yoshida H, Ohnishi K, Mori M, Terakawa S, Ohno R. Naito K, et al. Among authors: shinjo k. Leukemia. 2000 Aug;14(8):1436-43. doi: 10.1038/sj.leu.2401851. Leukemia. 2000. PMID: 10942240
166 results