Otter GM - Search Results

1

9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.

Su TL, Chou TC, Kim JY, Huang JT, Ciszewska G, Ren WY, Otter GM, Sirotnak FM, Watanabe KA. Su TL, et al. Among authors: otter gm. J Med Chem. 1995 Aug 18;38(17):3226-35. doi: 10.1021/jm00017a006. J Med Chem. 1995. PMID: 7650675

2

Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).

Su TL, Huang JT, Chou TC, Otter GM, Sirotnak FM, Watanabe KA. Su TL, et al. Among authors: otter gm. J Med Chem. 1988 Jun;31(6):1209-15. doi: 10.1021/jm00401a023. J Med Chem. 1988. PMID: 3373490

3

Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).

Piper JR, Johnson CA, Otter GM, Sirotnak FM. Piper JR, et al. Among authors: otter gm. J Med Chem. 1992 Aug 7;35(16):3002-6. doi: 10.1021/jm00094a011. J Med Chem. 1992. PMID: 1501226

4

Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.

Rumberger BG, Schmid FA, Otter GM, Sirotnak FM. Rumberger BG, et al. Among authors: otter gm. Cancer Commun. 1990;2(9):305-10. Cancer Commun. 1990. PMID: 2206778

5

Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.

Sirotnak FM, Schmid FA, Otter GM, Piper JR, Montgomery JA. Sirotnak FM, et al. Among authors: otter gm. Cancer Res. 1988 Oct 15;48(20):5686-91. Cancer Res. 1988. PMID: 3167828

6

Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives.

Sirotnak FM, Otter GM, Piper JR, DeGraw JI. Sirotnak FM, et al. Among authors: otter gm. Biochem Pharmacol. 1988 Dec 15;37(24):4775-7. doi: 10.1016/0006-2952(88)90351-6. Biochem Pharmacol. 1988. PMID: 3202909 No abstract available.

7

Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.

Piper JR, Johnson CA, Maddry JA, Malik ND, McGuire JJ, Otter GM, Sirotnak FM. Piper JR, et al. Among authors: otter gm. J Med Chem. 1993 Dec 24;36(26):4161-71. doi: 10.1021/jm00078a004. J Med Chem. 1993. PMID: 8277497

8

Effective combination therapy of metastatic murine solid tumors with edatrexate and the vinca alkaloids, vinblastine, navelbine and vindesine.

Otter GM, Sirotnak FM. Otter GM, et al. Cancer Chemother Pharmacol. 1994;33(4):286-90. doi: 10.1007/BF00685901. Cancer Chemother Pharmacol. 1994. PMID: 8281620

9

Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.

Sirotnak FM, Otter GM, Schmid FA. Sirotnak FM, et al. Among authors: otter gm. Cancer Res. 1993 Feb 1;53(3):587-91. Cancer Res. 1993. PMID: 8425192

10

Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro.

Chou TC, Otter GM, Sirotnak FM. Chou TC, et al. Among authors: otter gm. Cancer Chemother Pharmacol. 1996;37(3):222-8. doi: 10.1007/BF00688320. Cancer Chemother Pharmacol. 1996. PMID: 8529281

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