Mitch CH - Search Results

1

Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Sawyer BD, Mitch CH, Deeter JB, Peters SC, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P. Ward JS, et al. Among authors: mitch ch. J Med Chem. 1995 Sep 1;38(18):3469-81. doi: 10.1021/jm00018a007. J Med Chem. 1995. PMID: 7658434

2

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.

Ward JS, Merritt L, Klimkowski VJ, Lamb ML, Mitch CH, Bymaster FP, Sawyer B, Shannon HE, Olesen PH, Honoré T, et al. Ward JS, et al. Among authors: mitch ch. J Med Chem. 1992 Oct 30;35(22):4011-9. doi: 10.1021/jm00100a005. J Med Chem. 1992. PMID: 1433209

3

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines.

Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honoré T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, et al. Sauerberg P, et al. Among authors: mitch ch. J Med Chem. 1992 Jun 12;35(12):2274-83. doi: 10.1021/jm00090a019. J Med Chem. 1992. PMID: 1613751

4

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells.

Eckols K, Bymaster FP, Mitch CH, Shannon HE, Ward JS, DeLapp NW. Eckols K, et al. Among authors: mitch ch. Life Sci. 1995;57(12):1183-90. doi: 10.1016/0024-3205(95)02064-p. Life Sci. 1995. PMID: 7674807

5

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P. Shannon HE, et al. Among authors: mitch ch. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81. J Pharmacol Exp Ther. 1994. PMID: 7909557

6

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).

Bymaster FP, Wong DT, Mitch CH, Ward JS, Calligaro DO, Schoepp DD, Shannon HE, Sheardown MJ, Olesen PH, Suzdak PD, Swedberg MD, Sauerberg P. Bymaster FP, et al. Among authors: mitch ch. J Pharmacol Exp Ther. 1994 Apr;269(1):282-9. J Pharmacol Exp Ther. 1994. PMID: 7909558

7

Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens.

Shannon HE, Sawyer BD, Bemis KG, Bymaster FP, Health I, Mitch CH, Ward JS. Shannon HE, et al. Among authors: mitch ch. Eur J Pharmacol. 1993 Feb 23;232(1):47-57. doi: 10.1016/0014-2999(93)90727-y. Eur J Pharmacol. 1993. PMID: 8458395

8

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.

Mitch CH, Brown TJ, Bymaster FP, Calligaro DO, Dieckman D, Merrit L, Peters SC, Quimby SJ, Shannon HE, Shipley LA, Ward JS, Hansen K, Olesen PH, Sauerberg P, Sheardown MJ, Swedberg MD, Suzdak P, Greenwood B. Mitch CH, et al. J Med Chem. 1997 Feb 14;40(4):538-46. doi: 10.1021/jm9602470. J Med Chem. 1997. PMID: 9046345

9

In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.

Shannon HE, Womer DE, Bymaster FP, Calligaro DO, DeLapp NC, Mitch CH, Ward JS, Whitesitt CA, Swedberg MD, Sheardown MJ, Fink-Jensen A, Olesen PH, Rimvall K, Sauerberg P. Shannon HE, et al. Among authors: mitch ch. Life Sci. 1997;60(13-14):969-76. doi: 10.1016/s0024-3205(97)00036-2. Life Sci. 1997. PMID: 9121363 Review.

10

1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Mitch CH, Whitesitt C, Brunsting D, Sheardown MJ, Olesen PH, Swedberg MD, Jeppesen L, Sauerberg P. Ward JS, et al. Among authors: mitch ch. J Med Chem. 1998 Jan 29;41(3):379-92. doi: 10.1021/jm970125n. J Med Chem. 1998. PMID: 9464368

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