Timmerman H - Search Results

1

Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists.

Leurs R, Smit MJ, Meeder R, Ter Laak AM, Timmerman H. Leurs R, et al. Among authors: timmerman h. Biochem Biophys Res Commun. 1995 Sep 5;214(1):110-7. doi: 10.1006/bbrc.1995.2263. Biochem Biophys Res Commun. 1995. PMID: 7669031

2

Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study.

Ter Laak AM, Donné-Op den Kelder GM, Bast A, Timmerman H. Ter Laak AM, et al. Among authors: timmerman h. Eur J Pharmacol. 1993 Mar 2;232(2-3):199-205. doi: 10.1016/0014-2999(93)90774-c. Eur J Pharmacol. 1993. PMID: 8096817

3

Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists.

Leurs R, Smit MJ, Tensen CP, Ter Laak AM, Timmerman H. Leurs R, et al. Among authors: timmerman h. Biochem Biophys Res Commun. 1994 May 30;201(1):295-301. doi: 10.1006/bbrc.1994.1701. Biochem Biophys Res Commun. 1994. PMID: 8198587

4

Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors.

Bloemers SM, Leurs R, Smit MJ, Verheule S, Tertoolen LG, Timmerman H, de Laat SW. Bloemers SM, et al. Among authors: timmerman h. Biochem Biophys Res Commun. 1993 Feb 26;191(1):118-25. doi: 10.1006/bbrc.1993.1192. Biochem Biophys Res Commun. 1993. PMID: 8447817

5

Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.

ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. ter Laak AM, et al. Among authors: timmerman h. J Comput Aided Mol Des. 1995 Aug;9(4):319-30. doi: 10.1007/BF00125173. J Comput Aided Mol Des. 1995. PMID: 8523041

6

Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists.

Smit MJ, Roovers E, Timmerman H, van de Vrede Y, Alewijnse AE, Leurs R. Smit MJ, et al. Among authors: timmerman h. J Biol Chem. 1996 Mar 29;271(13):7574-82. doi: 10.1074/jbc.271.13.7574. J Biol Chem. 1996. PMID: 8631790 Free article.

7

The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation.

Smit MJ, Timmerman H, Blauw J, Beukers MW, Roovers E, Jacobs EH, Hoffmann M, Leurs R. Smit MJ, et al. Among authors: timmerman h. J Neurochem. 1996 Nov;67(5):1791-800. doi: 10.1046/j.1471-4159.1996.67051791.x. J Neurochem. 1996. PMID: 8863482

8

Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells.

Smit MJ, Timmerman H, Hijzelendoorn JC, Fukui H, Leurs R. Smit MJ, et al. Among authors: timmerman h. Br J Pharmacol. 1996 Mar;117(6):1071-80. doi: 10.1111/j.1476-5381.1996.tb16699.x. Br J Pharmacol. 1996. PMID: 8882599 Free PMC article.

9

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor.

Wieland K, Laak AM, Smit MJ, Kühne R, Timmerman H, Leurs R. Wieland K, et al. Among authors: timmerman h. J Biol Chem. 1999 Oct 15;274(42):29994-30000. doi: 10.1074/jbc.274.42.29994. J Biol Chem. 1999. PMID: 10514483 Free article.

We combined in a previously derived three-dimensional model of the histamine H(1) receptor (Ter Laak, A. M., Timmerman, H., Leurs, H., Nederkoorn, P. H. J., Smit, M. ...Design. 9, 319-330) a pharmacophore for the H(1) antagonist binding s …

We combined in a previously derived three-dimensional model of the histamine H(1) receptor (Ter Laak, A. M., Timmerman, H …

10

The histamine H3-receptor: a target for developing new drugs.

Leurs R, Timmerman H. Leurs R, et al. Among authors: timmerman h. Prog Drug Res. 1992;39:127-65. doi: 10.1007/978-3-0348-7144-0_4. Prog Drug Res. 1992. PMID: 1335582 Review. No abstract available.

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