A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away.
Vogel BE, Doelz R, Kadler KE, Hojima Y, Engel J, Prockop DJ.
Vogel BE, et al.
J Biol Chem. 1988 Dec 15;263(35):19249-55.
J Biol Chem. 1988.
PMID: 3198624
Free article.
In previous work (Vogel, B. E., Minor, R. R., Freund, M., and Prockop, D. J. (1987) J. Biol. Chem. 262, 14737-14744), we identified a single-base mutation that converted the glycine at position 748 of the alpha 1 chain of type I procollagen to a cysteine in a proband with …
In previous work (Vogel, B. E., Minor, R. R., Freund, M., and Prockop, D. J. (1987) J. Biol. Chem. 262, 14737-14744), we identified a …