Zhao B - Search Results

1

Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins.

Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R, et al. Johanson K, et al. Among authors: zhao b. J Biol Chem. 1995 Apr 21;270(16):9459-71. doi: 10.1074/jbc.270.16.9459. J Biol Chem. 1995. PMID: 7721873 Free article.

2

Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity.

Hoog SS, Towler EM, Zhao B, Doyle ML, Debouck C, Abdel-Meguid SS. Hoog SS, et al. Among authors: zhao b. Biochemistry. 1996 Aug 13;35(32):10279-86. doi: 10.1021/bi960179j. Biochemistry. 1996. PMID: 8756683

3

A paradigm for drug discovery using a conformation from the crystal structure of a presentation scaffold.

Zhao B, Helms LR, DesJarlais RL, Abdel-Meguid SS, Wetzel R. Zhao B, et al. Nat Struct Biol. 1995 Dec;2(12):1131-7. doi: 10.1038/nsb1295-1131. Nat Struct Biol. 1995. PMID: 8846226

4

Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors.

Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS. Zhao B, et al. Biochemistry. 1993 Dec 7;32(48):13054-60. doi: 10.1021/bi00211a015. Biochemistry. 1993. PMID: 8241159

5

Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis.

Abdel-Meguid SS, Zhao B, Murthy KH, Winborne E, Choi JK, DesJarlais RL, Minnich MD, Culp JS, Debouck C, Tomaszek TA Jr, et al. Abdel-Meguid SS, et al. Among authors: zhao b. Biochemistry. 1993 Aug 10;32(31):7972-80. doi: 10.1021/bi00082a019. Biochemistry. 1993. PMID: 8347601

6

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

Thompson SK, Smith WW, Zhao B, Halbert SM, Tomaszek TA, Tew DG, Levy MA, Janson CA, DAlessio KJ, McQueney MS, Kurdyla J, Jones CS, DesJarlais RL, Abdel-Meguid SS, Veber DF. Thompson SK, et al. Among authors: zhao b. J Med Chem. 1998 Oct 8;41(21):3923-7. doi: 10.1021/jm980474x. J Med Chem. 1998. PMID: 9767629

7

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.

LaLonde JM, Zhao B, Smith WW, Janson CA, DesJarlais RL, Tomaszek TA, Carr TJ, Thompson SK, Oh HJ, Yamashita DS, Veber DF, Abdel-Meguid SS. LaLonde JM, et al. Among authors: zhao b. J Med Chem. 1998 Nov 5;41(23):4567-76. doi: 10.1021/jm980249f. J Med Chem. 1998. PMID: 9804696

8

Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.

Marquis RW, Yamashita DS, Ru Y, LoCastro SM, Oh HJ, Erhard KF, DesJarlais RL, Head MS, Smith WW, Zhao B, Janson CA, Abdel-Meguid SS, Tomaszek TA, Levy MA, Veber DF. Marquis RW, et al. Among authors: zhao b. J Med Chem. 1998 Sep 10;41(19):3563-7. doi: 10.1021/jm980295f. J Med Chem. 1998. PMID: 9733481 No abstract available.

9

Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K.

Marquis RW, Ru Y, Yamashita DS, Oh HJ, Yen J, Thompson SK, Carr TJ, Levy MA, Tomaszek TA, Ijames CF, Smith WW, Zhao B, Janson CA, Abdel-Meguid SS, D'Alessio KJ, McQueney MS, Veber DF. Marquis RW, et al. Among authors: zhao b. Bioorg Med Chem. 1999 Apr;7(4):581-8. doi: 10.1016/s0968-0896(99)00011-5. Bioorg Med Chem. 1999. PMID: 10353637

10

Design of potent and selective human cathepsin K inhibitors that span the active site.

Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Lee-Rykaczewski L, James IE, Lark MW, Drake FH, Gowen M, Gleason JG, Veber DF. Thompson SK, et al. Among authors: zhao b. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14249-54. doi: 10.1073/pnas.94.26.14249. Proc Natl Acad Sci U S A. 1997. PMID: 9405598 Free PMC article.

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