Donowitz M - Search Results

1

Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors.

Levine SA, Nath SK, Yun CH, Yip JW, Montrose M, Donowitz M, Tse CM. Levine SA, et al. Among authors: donowitz m. J Biol Chem. 1995 Jun 9;270(23):13716-25. doi: 10.1074/jbc.270.23.13716. J Biol Chem. 1995. PMID: 7775426 Free article.

2

cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.

Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M. Cha B, et al. Among authors: donowitz m. J Biol Chem. 2005 Apr 29;280(17):16642-50. doi: 10.1074/jbc.M500505200. Epub 2005 Feb 18. J Biol Chem. 2005. PMID: 15722341 Free article.

3

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Zizak M, et al. Among authors: donowitz m. J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27. J Biol Chem. 2012. PMID: 22371496 Free PMC article.

4

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.

Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M. Yang J, et al. Among authors: donowitz m. J Biol Chem. 2013 Jun 7;288(23):16960-16974. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23. J Biol Chem. 2013. PMID: 23612977 Free PMC article.

5

AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.

Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M. Singh V, et al. Among authors: donowitz m. J Biol Chem. 2014 Feb 28;289(9):5449-61. doi: 10.1074/jbc.M113.521336. Epub 2014 Jan 7. J Biol Chem. 2014. PMID: 24398676 Free PMC article.

6

NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.

Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M. Yang J, et al. Among authors: donowitz m. J Biol Chem. 2014 Jul 18;289(29):20039-53. doi: 10.1074/jbc.M114.562413. Epub 2014 May 27. J Biol Chem. 2014. PMID: 24867958 Free PMC article.

7

Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site.

Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Chen T, et al. Among authors: donowitz m. J Biol Chem. 2015 Jan 23;290(4):1952-65. doi: 10.1074/jbc.M114.590174. Epub 2014 Dec 5. J Biol Chem. 2015. PMID: 25480791 Free PMC article.

8

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.

Cha B, Yang J, Singh V, Zachos NC, Sarker RI, Chen TE, Chakraborty M, Tse CM, Donowitz M. Cha B, et al. Among authors: donowitz m. J Biol Chem. 2017 May 19;292(20):8279-8290. doi: 10.1074/jbc.M116.774489. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283572 Free PMC article.

9

Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis.

Kim JH, Lee-Kwon W, Park JB, Ryu SH, Yun CH, Donowitz M. Kim JH, et al. Among authors: donowitz m. J Biol Chem. 2002 Jun 28;277(26):23714-24. doi: 10.1074/jbc.M200835200. Epub 2002 Apr 10. J Biol Chem. 2002. PMID: 11948184 Free article.

10

Short-term regulation of NHE3 by EGF and protein kinase C but not protein kinase A involves vesicle trafficking in epithelial cells and fibroblasts.

Donowitz M, Janecki A, Akhter S, Cavet ME, Sanchez F, Lamprecht G, Zizak M, Kwon WL, Khurana S, Yun CH, Tse CM. Donowitz M, et al. Ann N Y Acad Sci. 2000;915:30-42. doi: 10.1111/j.1749-6632.2000.tb05221.x. Ann N Y Acad Sci. 2000. PMID: 11193592 Review.

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