Friedlos F - Search Results

1

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1995 May 26;49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. Biochem Pharmacol. 1995. PMID: 7786305

2

The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink.

Friedlos F, Quinn J, Knox RJ, Roberts JJ. Friedlos F, et al. Biochem Pharmacol. 1992 Mar 17;43(6):1249-54. doi: 10.1016/0006-2952(92)90499-9. Biochem Pharmacol. 1992. PMID: 1562278

3

Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species.

Knox RJ, Friedlos F, Marchbank T, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1991 Oct 9;42(9):1691-7. doi: 10.1016/0006-2952(91)90503-w. Biochem Pharmacol. 1991. PMID: 1930294

4

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.

Roberts JJ, Marchbank T, Kotsaki-Kovatsi VP, Boland MP, Friedlos F, Knox RJ. Roberts JJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1989 Nov 15;38(22):4137-43. doi: 10.1016/0006-2952(89)90695-3. Biochem Pharmacol. 1989. PMID: 2480794

5

The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).

Knox RJ, Boland MP, Friedlos F, Coles B, Southan C, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1988 Dec 15;37(24):4671-7. doi: 10.1016/0006-2952(88)90336-x. Biochem Pharmacol. 1988. PMID: 3144286

6

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.

Knox RJ, Friedlos F, Jarman M, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1988 Dec 15;37(24):4661-9. doi: 10.1016/0006-2952(88)90335-8. Biochem Pharmacol. 1988. PMID: 3202902

7

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Anlezark GM, Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A. Anlezark GM, et al. Among authors: friedlos f. Biochem Pharmacol. 1995 Aug 25;50(5):609-18. doi: 10.1016/0006-2952(95)00187-5. Biochem Pharmacol. 1995. PMID: 7669063

8

Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme.

Mauger AB, Burke PJ, Somani HH, Friedlos F, Knox RJ. Mauger AB, et al. Among authors: friedlos f. J Med Chem. 1994 Oct 14;37(21):3452-8. doi: 10.1021/jm00047a002. J Med Chem. 1994. PMID: 7932574

9

Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954.

Knox RJ, Friedlos F, Biggs PJ, Flitter WD, Gaskell M, Goddard P, Davies L, Jarman M. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1993 Sep 1;46(5):797-803. doi: 10.1016/0006-2952(93)90487-h. Biochem Pharmacol. 1993. PMID: 8373433

10

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Boland MP. Knox RJ, et al. Among authors: friedlos f. Cancer Metastasis Rev. 1993 Jun;12(2):195-212. doi: 10.1007/BF00689810. Cancer Metastasis Rev. 1993. PMID: 8375021 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

59 results

Search Page

Filters