Knox RJ - Search Results

1

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF. Knox RJ, et al. Biochem Pharmacol. 1995 May 26;49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. Biochem Pharmacol. 1995. PMID: 7786305

2

Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2).

Friedlos F, Jarman M, Davies LC, Boland MP, Knox RJ. Friedlos F, et al. Among authors: knox rj. Biochem Pharmacol. 1992 Jul 7;44(1):25-31. doi: 10.1016/0006-2952(92)90033-f. Biochem Pharmacol. 1992. PMID: 1385952

3

Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system.

Friedlos F, Knox RJ. Friedlos F, et al. Among authors: knox rj. Biochem Pharmacol. 1992 Aug 18;44(4):631-5. doi: 10.1016/0006-2952(92)90396-z. Biochem Pharmacol. 1992. PMID: 1387314

4

Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity.

Friedlos F, Biggs PJ, Abrahamson JA, Knox RJ. Friedlos F, et al. Among authors: knox rj. Biochem Pharmacol. 1992 Nov 3;44(9):1739-43. doi: 10.1016/0006-2952(92)90067-s. Biochem Pharmacol. 1992. PMID: 1449531

5

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

Anlezark GM, Melton RG, Sherwood RF, Coles B, Friedlos F, Knox RJ. Anlezark GM, et al. Among authors: knox rj. Biochem Pharmacol. 1992 Dec 15;44(12):2289-95. doi: 10.1016/0006-2952(92)90671-5. Biochem Pharmacol. 1992. PMID: 1472094

6

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.

Knox RJ, Friedlos F, Sherwood RF, Melton RG, Anlezark GM. Knox RJ, et al. Biochem Pharmacol. 1992 Dec 15;44(12):2297-301. doi: 10.1016/0006-2952(92)90672-6. Biochem Pharmacol. 1992. PMID: 1472095

7

The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink.

Friedlos F, Quinn J, Knox RJ, Roberts JJ. Friedlos F, et al. Among authors: knox rj. Biochem Pharmacol. 1992 Mar 17;43(6):1249-54. doi: 10.1016/0006-2952(92)90499-9. Biochem Pharmacol. 1992. PMID: 1562278

8

Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species.

Knox RJ, Friedlos F, Marchbank T, Roberts JJ. Knox RJ, et al. Biochem Pharmacol. 1991 Oct 9;42(9):1691-7. doi: 10.1016/0006-2952(91)90503-w. Biochem Pharmacol. 1991. PMID: 1930294

9

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.

Roberts JJ, Marchbank T, Kotsaki-Kovatsi VP, Boland MP, Friedlos F, Knox RJ. Roberts JJ, et al. Among authors: knox rj. Biochem Pharmacol. 1989 Nov 15;38(22):4137-43. doi: 10.1016/0006-2952(89)90695-3. Biochem Pharmacol. 1989. PMID: 2480794

10

The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).

Knox RJ, Boland MP, Friedlos F, Coles B, Southan C, Roberts JJ. Knox RJ, et al. Biochem Pharmacol. 1988 Dec 15;37(24):4671-7. doi: 10.1016/0006-2952(88)90336-x. Biochem Pharmacol. 1988. PMID: 3144286

A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to a cytotoxic DNA interstrand crosslinking agent by reduction of its 4-nitro group to the corresponding hydroxylamino species (Roberts …

A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1 …

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