McDaniel R - Search Results

1

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.

McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. McDaniel R, et al. Nature. 1995 Jun 15;375(6532):549-54. doi: 10.1038/375549a0. Nature. 1995. PMID: 7791871

2

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.

McDaniel R, Ebert-Khosla S, Fu H, Hopwood DA, Khosla C. McDaniel R, et al. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11542-6. doi: 10.1073/pnas.91.24.11542. Proc Natl Acad Sci U S A. 1994. PMID: 7972098 Free PMC article.

3

Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase.

Fu H, McDaniel R, Hopwood DA, Khosla C. Fu H, et al. Among authors: mcdaniel r. Biochemistry. 1994 Aug 9;33(31):9321-6. doi: 10.1021/bi00197a036. Biochemistry. 1994. PMID: 8049233

A genetically engineered strain expressing the essential components of the tetracenomycin polyketide synthase (tcm PKS) along with the actinorhodin ketoreductase (act KR) was found to produce two new (diastereomeric) aromatic polyketides, designated RM20b and RM20c, in addition t …

A genetically engineered strain expressing the essential components of the tetracenomycin polyketide synthase (tcm PKS) along with the actin …

4

Engineered biosynthesis of novel polyketides.

McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. McDaniel R, et al. Science. 1993 Dec 3;262(5139):1546-50. doi: 10.1126/science.8248802. Science. 1993. PMID: 8248802

5

Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.

Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA. Khosla C, et al. Among authors: mcdaniel r. J Bacteriol. 1993 Apr;175(8):2197-204. doi: 10.1128/jb.175.8.2197-2204.1993. J Bacteriol. 1993. PMID: 8468280 Free PMC article.

6

Evolutionally guided enzyme design.

Khosla C, Caren R, Kao CM, McDaniel R, Wang SW. Khosla C, et al. Among authors: mcdaniel r. Biotechnol Bioeng. 1996 Oct 5;52(1):122-8. doi: 10.1002/(SICI)1097-0290(19961005)52:1<122::AID-BIT12>3.0.CO;2-Q. Biotechnol Bioeng. 1996. PMID: 18629858

7

Engineered intermodular and intramodular polyketide synthase fusions.

McDaniel R, Kao CM, Hwang SJ, Khosla C. McDaniel R, et al. Chem Biol. 1997 Sep;4(9):667-74. doi: 10.1016/s1074-5521(97)90222-2. Chem Biol. 1997. PMID: 9331407

8

Process development and metabolic engineering for the overproduction of natural and unnatural polyketides.

McDaniel R, Licari P, Khosla C. McDaniel R, et al. Adv Biochem Eng Biotechnol. 2001;73:31-52. doi: 10.1007/3-540-45300-8_3. Adv Biochem Eng Biotechnol. 2001. PMID: 11816811 Review.

9

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Ashley G. McDaniel R, et al. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1846-51. doi: 10.1073/pnas.96.5.1846. Proc Natl Acad Sci U S A. 1999. PMID: 10051557 Free PMC article.

10

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

Reeves CD, Murli S, Ashley GW, Piagentini M, Hutchinson CR, McDaniel R. Reeves CD, et al. Among authors: mcdaniel r. Biochemistry. 2001 Dec 25;40(51):15464-70. doi: 10.1021/bi015864r. Biochemistry. 2001. PMID: 11747421

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