O'Malley SS - Search Results

1

Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Siegl PK, Kivlighn SD, Lotti VJ, Chang RS, et al. Chang LL, et al. J Med Chem. 1994 Dec 23;37(26):4464-78. doi: 10.1021/jm00052a006. J Med Chem. 1994. PMID: 7799397

2

Benzodiazepines as potent and selective bradykinin B1 antagonists.

Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, Chen TB, Harrell CM, Chang RS, Sandhu P, Ellis JD, Bondiskey PJ, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. J Med Chem. 2003 May 8;46(10):1803-6. doi: 10.1021/jm034020y. J Med Chem. 2003. PMID: 12723943

3

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Kivlighn SD, Siegl PK, Lotti VJ, Chang RS, et al. Chang LL, et al. J Med Chem. 1995 Sep 15;38(19):3741-58. doi: 10.1021/jm00019a004. J Med Chem. 1995. PMID: 7562905

4

In vitro pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors.

Chang RS, Lotti VJ, Chen TB, O'Malley SS, Bendesky RJ, Kling PJ, Kivlighn SD, Siegl PK, Ondeyka D, Greenlee WJ, et al. Chang RS, et al. Eur J Pharmacol. 1995 Dec 29;294(2-3):429-37. doi: 10.1016/0014-2999(95)00563-3. Eur J Pharmacol. 1995. PMID: 8750703

5

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists.

Barrow JC, Glass KL, Selnick HG, Freidinger RM, Chang RS, O'Malley SS, Woyden C. Barrow JC, et al. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1917-20. doi: 10.1016/s0960-894x(00)00374-7. Bioorg Med Chem Lett. 2000. PMID: 10987417

6

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Barrow JC, Nantermet PG, Selnick HG, Glass KL, Rittle KE, Gilbert KF, Steele TG, Homnick CF, Freidinger RM, Ransom RW, Kling P, Reiss D, Broten TP, Schorn TW, Chang RS, O'Malley SS, Olah TV, Ellis JD, Barrish A, Kassahun K, Leppert P, Nagarathnam D, Forray C. Barrow JC, et al. J Med Chem. 2000 Jul 13;43(14):2703-18. doi: 10.1021/jm990612y. J Med Chem. 2000. PMID: 10893308

7

Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.

Patane MA, DiPardo RM, Price RP, Chang RS, Ransom RW, O'Malley SS, Di Salvo J, Bock MG. Patane MA, et al. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2495-500. doi: 10.1016/s0960-894x(98)00451-x. Bioorg Med Chem Lett. 1998. PMID: 9873568

8

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.

Nantermet PG, Barrow JC, Selnick HG, Homnick CF, Freidinger RM, Chang RS, O'Malley SS, Reiss DR, Broten TP, Ransom RW, Pettibone DJ, Olah T, Forray C. Nantermet PG, et al. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1625-8. doi: 10.1016/s0960-894x(99)00696-4. Bioorg Med Chem Lett. 2000. PMID: 10937710

9

Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues.

O'Malley SS, Chen TB, Francis BE, Gibson RE, Burns HD, DiSalvo J, Bayne ML, Wetzel JM, Nagarathnam D, Marzabadi M, Gluchowski C, Chang RS. O'Malley SS, et al. Eur J Pharmacol. 1998 May 8;348(2-3):287-95. doi: 10.1016/s0014-2999(98)00149-6. Eur J Pharmacol. 1998. PMID: 9652345

10

Design and synthesis of novel dihydropyridine alpha-1a antagonists.

Marzabadi MR, Hong X, Nagarathnam D, Miao SW, Chiu G, Wong WC, Wetzel JM, Fang J, Forray C, Chen TB, O'Malley SS, Chang RS, Gluchowski C. Marzabadi MR, et al. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. doi: 10.1016/s0960-894x(99)00484-9. Bioorg Med Chem Lett. 1999. PMID: 10522703

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