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Antiviral L-nucleosides specific for hepatitis B virus infection.
Bryant ML, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Marion P, Cretton-Scott E, Schinazi RF, Sommadossi JP. Bryant ML, et al. Among authors: faraj a. Antimicrob Agents Chemother. 2001 Jan;45(1):229-35. doi: 10.1128/AAC.45.1.229-235.2001. Antimicrob Agents Chemother. 2001. PMID: 11120971 Free PMC article.
Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus.
Hernandez-Santiago B, Placidi L, Cretton-Scott E, Faraj A, Bridges EG, Bryant ML, Rodriguez-Orengo J, Imbach JL, Gosselin G, Pierra C, Dukhan D, Sommadossi JP. Hernandez-Santiago B, et al. Among authors: faraj a. Antimicrob Agents Chemother. 2002 Jun;46(6):1728-33. doi: 10.1128/AAC.46.6.1728-1733.2002. Antimicrob Agents Chemother. 2002. PMID: 12019082 Free PMC article.
Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.
Faraj A, El Alaoui AM, Gosselin G, Imbach JL, Morrow C, Sommadossi JP. Faraj A, et al. Antiviral Res. 2000 Aug;47(2):97-102. doi: 10.1016/s0166-3542(00)00095-4. Antiviral Res. 2000. PMID: 10996397
However, the inhibitory effect of L-AZTTP towards HIV-1 RT was very modest (266-fold less potent) when compared to its isomer beta-D-AZT 5'-triphosphate (D-AZTTP) which exhibits a K(i) value of 0.0075 microM and this finding was further confirmed by DNA chain termination a …
However, the inhibitory effect of L-AZTTP towards HIV-1 RT was very modest (266-fold less potent) when compared to its isomer beta-D-AZT 5'- …
Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.
Placidi L, Faraj A, Loi AG, Pierra C, Egron D, Cretton-Scott E, Gosseli G, Périgaud C, Martin LT, Schinazi RF, Imbach JL, el Kouni MH, Bryant ML, Sommadossi JP. Placidi L, et al. Among authors: faraj a. Antivir Chem Chemother. 2001 Mar;12(2):99-108. doi: 10.1177/095632020101200203. Antivir Chem Chemother. 2001. PMID: 11527047 Free article.
238 results