Hargreaves RJ - Search Results

1

Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin- 2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor.

Castro JL, Baker R, Guiblin AR, Hobbs SC, Jenkins MR, Russell MG, Beer MS, Stanton JA, Scholey K, Hargreaves RJ, et al. Castro JL, et al. Among authors: hargreaves rj. J Med Chem. 1994 Sep 16;37(19):3023-32. doi: 10.1021/jm00045a006. J Med Chem. 1994. PMID: 7932524

2

L-694,247: a potent 5-HT1D receptor agonist.

Beer MS, Stanton JA, Bevan Y, Heald A, Reeve AJ, Street LJ, Matassa VG, Hargreaves RJ, Middlemiss DN. Beer MS, et al. Among authors: hargreaves rj. Br J Pharmacol. 1993 Nov;110(3):1196-200. doi: 10.1111/j.1476-5381.1993.tb13941.x. Br J Pharmacol. 1993. PMID: 8298808 Free PMC article.

3

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.

Showell GA, Baker R, Davis J, Hargreaves R, Freedman SB, Hoogsteen K, Patel S, Snow RJ. Showell GA, et al. Among authors: hargreaves r. J Med Chem. 1992 Mar 6;35(5):911-6. doi: 10.1021/jm00083a016. J Med Chem. 1992. PMID: 1548680

4

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD. Rowley M, et al. J Med Chem. 1997 Dec 5;40(25):4053-68. doi: 10.1021/jm970417o. J Med Chem. 1997. PMID: 9406596

5

The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo.

Freedman SB, Dawson GR, Iversen LL, Baker R, Hargreaves RJ. Freedman SB, et al. Among authors: hargreaves rj. Life Sci. 1993;52(5-6):489-95. doi: 10.1016/0024-3205(93)90306-n. Life Sci. 1993. PMID: 8441329 Review.

6

N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.

Ladduwahetty T, Baker R, Cascieri MA, Chambers MS, Haworth K, Keown LE, MacIntyre DE, Metzger JM, Owen S, Rycroft W, Sadowski S, Seward EM, Shepheard SL, Swain CJ, Tattersall FD, Watt AP, Williamson DW, Hargreaves RJ. Ladduwahetty T, et al. Among authors: hargreaves rj. J Med Chem. 1996 Jul 19;39(15):2907-14. doi: 10.1021/jm9506534. J Med Chem. 1996. PMID: 8709125

7

Differential effects of 5-HT1B/1D receptor agonists on neurogenic dural plasma extravasation and vasodilation in anaesthetized rats.

Shepherd SL, Williamson DJ, Beer MS, Hill RG, Hargreaves RJ. Shepherd SL, et al. Among authors: hargreaves rj. Neuropharmacology. 1997 Apr-May;36(4-5):525-33. doi: 10.1016/s0028-3908(97)00057-9. Neuropharmacology. 1997. PMID: 9225277

8

A second generation of non-peptide cholecystokinin receptor antagonists and their possible therapeutic potential.

Freedman SB, Patel S, Smith AJ, Chapman K, Fletcher A, Kemp JA, Marshall GR, Hargreaves RJ, Scholey K, Mellin EC, et al. Freedman SB, et al. Among authors: hargreaves rj. Ann N Y Acad Sci. 1994 Mar 23;713:312-8. doi: 10.1111/j.1749-6632.1994.tb44079.x. Ann N Y Acad Sci. 1994. PMID: 8185173 Review.

9

L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.

Hargreaves RJ, McKnight AT, Scholey K, Newberry NR, Street LJ, Hutson PH, Semark JE, Harley EA, Patel S, Freedman SB. Hargreaves RJ, et al. Br J Pharmacol. 1992 Oct;107(2):494-501. doi: 10.1111/j.1476-5381.1992.tb12773.x. Br J Pharmacol. 1992. PMID: 1422595 Free PMC article.

10

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.

Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tattersall FD, et al. Among authors: hargreaves rj. Neuropharmacology. 1996;35(8):1121-9. doi: 10.1016/s0028-3908(96)00020-2. Neuropharmacology. 1996. PMID: 9121615

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