Harth G - Search Results

1

Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity.

Harth G, Clemens DL, Horwitz MA. Harth G, et al. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9342-6. doi: 10.1073/pnas.91.20.9342. Proc Natl Acad Sci U S A. 1994. PMID: 7937767 Free PMC article.

2

Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology.

Harth G, Horwitz MA, Tabatadze D, Zamecnik PC. Harth G, et al. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15614-9. doi: 10.1073/pnas.242612299. Epub 2002 Nov 11. Proc Natl Acad Sci U S A. 2002. PMID: 12427974 Free PMC article.

3

Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.

Harth G, Horwitz MA. Harth G, et al. Infect Immun. 2003 Jan;71(1):456-64. doi: 10.1128/IAI.71.1.456-464.2003. Infect Immun. 2003. PMID: 12496196 Free PMC article.

4

Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs.

Tullius MV, Harth G, Horwitz MA. Tullius MV, et al. Among authors: harth g. Infect Immun. 2003 Jul;71(7):3927-36. doi: 10.1128/IAI.71.7.3927-3936.2003. Infect Immun. 2003. PMID: 12819079 Free PMC article.

5

All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.

Harth G, Maslesa-Galić S, Tullius MV, Horwitz MA. Harth G, et al. Mol Microbiol. 2005 Nov;58(4):1157-72. doi: 10.1111/j.1365-2958.2005.04899.x. Mol Microbiol. 2005. PMID: 16262797 Free article.

6

Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis.

Harth G, Zamecnik PC, Tabatadze D, Pierson K, Horwitz MA. Harth G, et al. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7199-204. doi: 10.1073/pnas.0701725104. Epub 2007 Apr 16. Proc Natl Acad Sci U S A. 2007. PMID: 17438292 Free PMC article.

7

Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.

Horwitz MA, Lee BW, Dillon BJ, Harth G. Horwitz MA, et al. Among authors: harth g. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1530-4. doi: 10.1073/pnas.92.5.1530. Proc Natl Acad Sci U S A. 1995. PMID: 7878014 Free PMC article.

8

Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis.

Harth G, Lee BY, Wang J, Clemens DL, Horwitz MA. Harth G, et al. Infect Immun. 1996 Aug;64(8):3038-47. doi: 10.1128/iai.64.8.3038-3047.1996. Infect Immun. 1996. PMID: 8757831 Free PMC article.

9

High-level heterologous expression and secretion in rapidly growing nonpathogenic mycobacteria of four major Mycobacterium tuberculosis extracellular proteins considered to be leading vaccine candidates and drug targets.

Harth G, Lee BY, Horwitz MA. Harth G, et al. Infect Immun. 1997 Jun;65(6):2321-8. doi: 10.1128/iai.65.6.2321-2328.1997. Infect Immun. 1997. PMID: 9169770 Free PMC article.

10

Expression and efficient export of enzymatically active Mycobacterium tuberculosis glutamine synthetase in Mycobacterium smegmatis and evidence that the information for export is contained within the protein.

Harth G, Horwitz MA. Harth G, et al. J Biol Chem. 1997 Sep 5;272(36):22728-35. doi: 10.1074/jbc.272.36.22728. J Biol Chem. 1997. PMID: 9278431 Free article.

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