Korzekwa KR - Search Results

1

Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.

Zhou D, Cam LL, Laughton CA, Korzekwa KR, Chen S. Zhou D, et al. Among authors: korzekwa kr. J Biol Chem. 1994 Jul 29;269(30):19501-8. J Biol Chem. 1994. PMID: 8034720 Free article.

2

Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

Kao YC, Korzekwa KR, Laughton CA, Chen S. Kao YC, et al. Among authors: korzekwa kr. Eur J Biochem. 2001 Jan;268(2):243-51. doi: 10.1046/j.1432-1033.2001.01886.x. Eur J Biochem. 2001. PMID: 11168357 Free article.

3

A site-directed mutagenesis study of human placental aromatase.

Zhou DJ, Korzekwa KR, Poulos T, Chen SA. Zhou DJ, et al. Among authors: korzekwa kr. J Biol Chem. 1992 Jan 15;267(2):762-8. J Biol Chem. 1992. PMID: 1730667 Free article.

4

Use of aromatase (CYP19) metabolite ratios to characterize electron transfer from NADPH-cytochrome P450 reductase.

Grogan J, Shou M, Zhou D, Chen S, Korzekwa KR. Grogan J, et al. Among authors: korzekwa kr. Biochemistry. 1993 Nov 16;32(45):12007-12. doi: 10.1021/bi00096a010. Biochemistry. 1993. PMID: 8218277

5

A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

Shou M, Dai R, Cui D, Korzekwa KR, Baillie TA, Rushmore TH. Shou M, et al. Among authors: korzekwa kr. J Biol Chem. 2001 Jan 19;276(3):2256-62. doi: 10.1074/jbc.M008799200. Epub 2000 Oct 27. J Biol Chem. 2001. PMID: 11054425 Free article.

6

Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine.

Aoyama T, Korzekwa K, Nagata K, Adesnik M, Reiss A, Lapenson DP, Gillette J, Gelboin HV, Waxman DJ, Gonzalez FJ. Aoyama T, et al. J Biol Chem. 1989 Dec 15;264(35):21327-33. J Biol Chem. 1989. PMID: 2574176 Free article.

7

Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation.

Hanioka N, Gonzalez FJ, Lindberg NA, Liu G, Gelboin HV, Korzekwa KR. Hanioka N, et al. Among authors: korzekwa kr. Biochemistry. 1992 Apr 7;31(13):3364-70. doi: 10.1021/bi00128a009. Biochemistry. 1992. PMID: 1554718

8

Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like molecules.

McMasters DR, Torres RA, Crathern SJ, Dooney DL, Nachbar RB, Sheridan RP, Korzekwa KR. McMasters DR, et al. Among authors: korzekwa kr. J Med Chem. 2007 Jul 12;50(14):3205-13. doi: 10.1021/jm0700060. Epub 2007 Jun 9. J Med Chem. 2007. PMID: 17559204 Free PMC article.

9

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

Shou M, Grogan J, Mancewicz JA, Krausz KW, Gonzalez FJ, Gelboin HV, Korzekwa KR. Shou M, et al. Among authors: korzekwa kr. Biochemistry. 1994 May 31;33(21):6450-5. doi: 10.1021/bi00187a009. Biochemistry. 1994. PMID: 8204577

10

The effects of diabetes on placental aromatase activity.

McRobie DJ, Korzekwa KR, Glover DD, Tracy TS. McRobie DJ, et al. Among authors: korzekwa kr. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):147-53. doi: 10.1016/s0960-0760(97)00088-5. J Steroid Biochem Mol Biol. 1997. PMID: 9449216

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