Laughton CA - Search Results

1

Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.

Zhou D, Cam LL, Laughton CA, Korzekwa KR, Chen S. Zhou D, et al. Among authors: laughton ca. J Biol Chem. 1994 Jul 29;269(30):19501-8. J Biol Chem. 1994. PMID: 8034720 Free article.

2

Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase.

Chen S, Kao YC, Laughton CA. Chen S, et al. Among authors: laughton ca. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):107-15. J Steroid Biochem Mol Biol. 1997. PMID: 9365179

3

Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

Kao YC, Korzekwa KR, Laughton CA, Chen S. Kao YC, et al. Among authors: laughton ca. Eur J Biochem. 2001 Jan;268(2):243-51. doi: 10.1046/j.1432-1033.2001.01886.x. Eur J Biochem. 2001. PMID: 11168357 Free article.

4

Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.

Kao YC, Cam LL, Laughton CA, Zhou D, Chen S. Kao YC, et al. Among authors: laughton ca. Cancer Res. 1996 Aug 1;56(15):3451-60. Cancer Res. 1996. PMID: 8758911

5

Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

Kao YC, Zhou C, Sherman M, Laughton CA, Chen S. Kao YC, et al. Among authors: laughton ca. Environ Health Perspect. 1998 Feb;106(2):85-92. doi: 10.1289/ehp.9810685. Environ Health Perspect. 1998. PMID: 9435150 Free PMC article.

6

Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.

Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Laughton CA, et al. J Med Chem. 1990 Sep;33(9):2673-9. doi: 10.1021/jm00171a052. J Med Chem. 1990. PMID: 2391706

7

A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.

Laughton CA, Neidle S, Zvelebil MJ, Sternberg MJ. Laughton CA, et al. Biochem Biophys Res Commun. 1990 Sep 28;171(3):1160-7. doi: 10.1016/0006-291x(90)90806-x. Biochem Biophys Res Commun. 1990. PMID: 2222435

8

A detailed molecular model for human aromatase.

Laughton CA, Zvelebil MJ, Neidle S. Laughton CA, et al. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):399-407. doi: 10.1016/0960-0760(93)90243-p. J Steroid Biochem Mol Biol. 1993. PMID: 8476753

9

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.

Laughton CA, Neidle S. Laughton CA, et al. J Med Chem. 1990 Nov;33(11):3055-60. doi: 10.1021/jm00173a023. J Med Chem. 1990. PMID: 2231605

10

Rationally designed analogues of tamoxifen with improved calmodulin antagonism.

Hardcastle IR, Rowlands MG, Houghton J, Parr IB, Potter GA, Jarman M, Edwards KJ, Laughton CA, Trent JO, Neidle S. Hardcastle IR, et al. Among authors: laughton ca. J Med Chem. 1995 Jan 20;38(2):241-8. doi: 10.1021/jm00002a005. J Med Chem. 1995. PMID: 7830266

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