Kohn LD - Search Results

1

Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies.

Kosugi S, Ban T, Akamizu T, Valente W, Kohn LD. Kosugi S, et al. Among authors: kohn ld. J Clin Endocrinol Metab. 1993 Jul;77(1):19-24. doi: 10.1210/jcem.77.1.8100829. J Clin Endocrinol Metab. 1993. PMID: 8100829

2

Regulation of thyrotropin receptor gene expression in rat FRTL-5 thyroid cells.

Saji M, Akamizu T, Sanchez M, Obici S, Avvedimento E, Gottesman ME, Kohn LD. Saji M, et al. Among authors: kohn ld. Endocrinology. 1992 Jan;130(1):520-33. doi: 10.1210/endo.130.1.1309347. Endocrinology. 1992. PMID: 1309347

3

Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.

Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD. Kosugi S, et al. Among authors: kohn ld. J Biol Chem. 1992 Dec 5;267(34):24153-6. J Biol Chem. 1992. PMID: 1332945 Free article.

4

Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies.

Kosugi S, Ban T, Akamizu T, Kohn LD. Kosugi S, et al. Among authors: kohn ld. Biochem Biophys Res Commun. 1992 Dec 30;189(3):1754-62. doi: 10.1016/0006-291x(92)90281-o. Biochem Biophys Res Commun. 1992. PMID: 1336379

5

Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors.

Kosugi S, Ban T, Akamizu T, Kohn LD. Kosugi S, et al. Among authors: kohn ld. Mol Endocrinol. 1992 Feb;6(2):168-80. doi: 10.1210/mend.6.2.1349156. Mol Endocrinol. 1992. PMID: 1349156

6

Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon.

Saji M, Moriarty J, Ban T, Singer DS, Kohn LD. Saji M, et al. Among authors: kohn ld. J Clin Endocrinol Metab. 1992 Sep;75(3):871-8. doi: 10.1210/jcem.75.3.1381373. J Clin Endocrinol Metab. 1992. PMID: 1381373

7

Specific antibody to the thyrotropin receptor identifies multiple receptor forms in membranes of cells transfected with wild-type receptor complementary deoxyribonucleic acid: characterization of their relevance to receptor synthesis, processing, structure, and function.

Ban T, Kosugi S, Kohn LD. Ban T, et al. Among authors: kohn ld. Endocrinology. 1992 Aug;131(2):815-29. doi: 10.1210/endo.131.2.1639025. Endocrinology. 1992. PMID: 1639025

8

Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains.

Kosugi S, Ban T, Akamizu T, Kohn LD. Kosugi S, et al. Among authors: kohn ld. J Biol Chem. 1991 Oct 15;266(29):19413-8. J Biol Chem. 1991. PMID: 1655787 Free article.

9

Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies.

Akamizu T, Ikuyama S, Saji M, Kosugi S, Kozak C, McBride OW, Kohn LD. Akamizu T, et al. Among authors: kohn ld. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5677-81. doi: 10.1073/pnas.87.15.5677. Proc Natl Acad Sci U S A. 1990. PMID: 1696008 Free PMC article.

10

Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients.

Kosugi S, Ban T, Akamizu T, Kohn LD. Kosugi S, et al. Among authors: kohn ld. Biochem Biophys Res Commun. 1991 Oct 31;180(2):1118-24. doi: 10.1016/s0006-291x(05)81182-9. Biochem Biophys Res Commun. 1991. PMID: 1719963

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