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Page 1
Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant.
Hedstrom L, Perona JJ, Rutter WJ. Hedstrom L, et al. Biochemistry. 1994 Jul 26;33(29):8757-63. doi: 10.1021/bi00195a017. Biochemistry. 1994. PMID: 8038165
However, chymotrypsin-like substrate specificity is attained when two surface loops are changed to the analogous residues of chymotrypsin, in conjunction with the changes in the S1 binding site [Hedstrom, L., Szilagyi, L., & Rutter, W. J. (1992) Science 2 …
However, chymotrypsin-like substrate specificity is attained when two surface loops are changed to the analogous residues of chymotrypsin, i …
Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity.
Hedstrom L, Farr-Jones S, Kettner CA, Rutter WJ. Hedstrom L, et al. Biochemistry. 1994 Jul 26;33(29):8764-9. doi: 10.1021/bi00195a018. Biochemistry. 1994. PMID: 8038166
Rat trypsin II has been converted to a protease with chymotrypsin-like substrate specificity [Hedstrom, L., et al. (1994) Biochemistry (preceding paper in this issue)]. The key alteration in this conversion is the exchange of two surface loops for the analogous loop …
Rat trypsin II has been converted to a protease with chymotrypsin-like substrate specificity [Hedstrom, L., et al. (1994) Bioc …
Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles.
Schellenberger V, Turck CW, Hedstrom L, Rutter WJ. Schellenberger V, et al. Among authors: hedstrom l. Biochemistry. 1993 Apr 27;32(16):4349-53. doi: 10.1021/bi00067a026. Biochemistry. 1993. PMID: 8476865
As a first application, we investigated the S'1 subsite specificity of chymotrypsin, trypsin, and a recently described trypsin mutant, Tr-->Ch[S1 + L1 + L2] with chymotrypsin-like primary specificity [Hedstrom, L., Szilagyi, L., & Rutter, W. J. (1992) …
As a first application, we investigated the S'1 subsite specificity of chymotrypsin, trypsin, and a recently described trypsin mutant, Tr--& …
172 results