Sesnie JA - Search Results

1

Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.

Hagen SE, Domagala JM, Gracheck SJ, Sesnie JA, Stier MA, Suto MJ. Hagen SE, et al. Among authors: sesnie ja. J Med Chem. 1994 Mar 18;37(6):733-8. doi: 10.1021/jm00032a005. J Med Chem. 1994. PMID: 8145222

2

5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials.

Domagala JM, Hagen SE, Hutt MP, Sanchez JP, Sesnie J, Trehan AK. Domagala JM, et al. Drugs Exp Clin Res. 1988;14(7):453-60. Drugs Exp Clin Res. 1988. PMID: 2853667

3

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity.

Sanchez JP, Domagala JM, Heifetz CL, Priebe SR, Sesnie JA, Trehan AK. Sanchez JP, et al. Among authors: sesnie ja. J Med Chem. 1992 May 15;35(10):1764-73. doi: 10.1021/jm00088a011. J Med Chem. 1992. PMID: 1366133

4

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.

Domagala JM, Bridges AJ, Culbertson TP, Gambino L, Hagen SE, Karrick G, Porter K, Sanchez JP, Sesnie JA, Spense FG, et al. Domagala JM, et al. Among authors: sesnie ja. J Med Chem. 1991 Mar;34(3):1142-54. doi: 10.1021/jm00107a039. J Med Chem. 1991. PMID: 1848296

5

The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents.

Sanchez JP, Gogliotti RD, Domagala JM, Gracheck SJ, Huband MD, Sesnie JA, Cohen MA, Shapiro MA. Sanchez JP, et al. Among authors: sesnie ja. J Med Chem. 1995 Oct 27;38(22):4478-87. doi: 10.1021/jm00022a013. J Med Chem. 1995. PMID: 7473575

6

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.

Domagala JM, Hagen SE, Joannides T, Kiely JS, Laborde E, Schroeder MC, Sesnie JA, Shapiro MA, Suto MJ, Vanderroest S. Domagala JM, et al. Among authors: sesnie ja. J Med Chem. 1993 Apr 2;36(7):871-82. doi: 10.1021/jm00059a012. J Med Chem. 1993. PMID: 8385225

7

Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships.

Culbertson TP, Sanchez JP, Gambino L, Sesnie JA. Culbertson TP, et al. Among authors: sesnie ja. J Med Chem. 1990 Aug;33(8):2270-5. doi: 10.1021/jm00170a035. J Med Chem. 1990. PMID: 2374153

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