Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders.
Masciocchi S, Businaro P, Greco G, Scaranzin S, Malvaso A, Morandi C, Zardini E, Risi M, Vegezzi E, Diamanti L, Bini P, Siquilini S, Giannoccaro MP, Morelli L, Liguori R, Patti F, De Giuli V, Portaccio E, Zanetta C, Bergamoni S, Simone AM, Lanzillo R, Bruno G, Gallo A, Bisecco A, Di Filippo M, Pauri F, Toriello A, Barone P, Tazza F, Bucello S, Banfi P, Fabris M, Volonghi I, Raciti L, Vigliani MC, Bocci T, Paoletti M, Colombo E, Filippi M, Pichiecchio A, Marchioni E, Franciotta D, Gastaldi M; Neuroimmunology platform study group (PNI).
Masciocchi S, et al.
Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200359. doi: 10.1212/NXI.0000000000200359. Epub 2025 Jan 17.
Neurol Neuroimmunol Neuroinflamm. 2025.
PMID: 39823554
PLP1-IgG a) colocalized with their target on CBA-TBA, where their binding was abolished after immunoadsorption and fixation-induced conformational epitope alteration; b) mostly pertained to the IgG1/IgG3 subclass (68.3%) and were able to induce CDC; and c) coreacted with D …
PLP1-IgG a) colocalized with their target on CBA-TBA, where their binding was abolished after immunoadsorption and fixation-induced conforma …