Rittle KE - Search Results

1

Nanomolar-affinity, non-peptide oxytocin receptor antagonists.

Evans BE, Lundell GF, Gilbert KF, Bock MG, Rittle KE, Carroll LA, Williams PD, Pawluczyk JM, Leighton JL, Young MB, et al. Evans BE, et al. Among authors: rittle ke. J Med Chem. 1993 Dec 10;36(25):3993-4005. doi: 10.1021/jm00077a002. J Med Chem. 1993. PMID: 8258821

2

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

Nantermet PG, Barrow JC, Lundell GF, Pellicore JM, Rittle KE, Young M, Freidinger RM, Connolly TM, Condra C, Karczewski J, Bednar RA, Gaul SL, Gould RJ, Prendergast K, Selnick HG. Nantermet PG, et al. Among authors: rittle ke. Bioorg Med Chem Lett. 2002 Feb 11;12(3):319-23. doi: 10.1016/s0960-894x(01)00745-4. Bioorg Med Chem Lett. 2002. PMID: 11814787

3

Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Whitter WL, Veber DF, Freidinger RM, Chang RS, Chen TB, Lotti VJ. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1990 Jan;33(1):450-5. doi: 10.1021/jm00163a069. J Med Chem. 1990. PMID: 2153212

4

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.

Evans BE, Rittle KE, Bock MG, DiPardo RM, Freidinger RM, Whitter WL, Lundell GF, Veber DF, Anderson PS, Chang RS, et al. Evans BE, et al. Among authors: rittle ke. J Med Chem. 1988 Dec;31(12):2235-46. doi: 10.1021/jm00120a002. J Med Chem. 1988. PMID: 2848124

5

Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.

Evans BE, Rittle KE, Bock MG, DiPardo RM, Freidinger RM, Whitter WL, Gould NP, Lundell GF, Homnick CF, Veber DF, et al. Evans BE, et al. Among authors: rittle ke. J Med Chem. 1987 Jul;30(7):1229-39. doi: 10.1021/jm00390a019. J Med Chem. 1987. PMID: 2885419

6

Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Whitter WL, Veber DE, Anderson PS, Freidinger RM. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1989 Jan;32(1):13-6. doi: 10.1021/jm00121a004. J Med Chem. 1989. PMID: 2909725 No abstract available.

7

Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.

Bock MG, DiPardo RM, Evans BE, Freidinger RM, Rittle KE, Payne LS, Boger J, Whitter WL, LaMont BI, Ulm EH, et al. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1988 Oct;31(10):1918-23. doi: 10.1021/jm00118a009. J Med Chem. 1988. PMID: 3050088

8

Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Boger J, Poe M, LaMont BI, Lynch RJ, Ulm EH, Vlasuk GP, et al. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1987 Oct;30(10):1853-7. doi: 10.1021/jm00393a029. J Med Chem. 1987. PMID: 3309316

9

Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Veber DF, Freidinger RM, Chang RS, Lotti VJ. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1988 Jan;31(1):176-81. doi: 10.1021/jm00396a028. J Med Chem. 1988. PMID: 3336017

10

Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Freidinger RM, Chang RS, Lotti VJ. Bock MG, et al. Among authors: rittle ke. J Med Chem. 1988 Jan;31(1):264-8. doi: 10.1021/jm00396a042. J Med Chem. 1988. PMID: 3336026 No abstract available.

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