Aldern KA - Search Results

1

Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus.

Hostetler KY, Parker S, Sridhar CN, Martin MJ, Li JL, Stuhmiller LM, van Wijk GM, van den Bosch H, Gardner MF, Aldern KA, et al. Hostetler KY, et al. Among authors: aldern ka. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11835-9. doi: 10.1073/pnas.90.24.11835. Proc Natl Acad Sci U S A. 1993. PMID: 8265634 Free PMC article.

2

Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro.

Hostetler KY, Kini GD, Beadle JR, Aldern KA, Gardner MF, Border R, Kumar R, Barshak L, Sridhar CN, Wheeler CJ, Richman DD. Hostetler KY, et al. Among authors: aldern ka. Antiviral Res. 1996 Jun;31(1-2):59-67. doi: 10.1016/0166-3542(96)00947-3. Antiviral Res. 1996. PMID: 8793009

3

Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis.

Taskintuna I, Banker AS, Flores-Aguilar M, Bergeron-Lynn G, Aldern KA, Hostetler KY, Freeman WR. Taskintuna I, et al. Among authors: aldern ka. Retina. 1997;17(1):57-64. doi: 10.1097/00006982-199701000-00011. Retina. 1997. PMID: 9051844

4

Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells.

Beadle JR, Kini GD, Aldern KA, Gardner MF, Wright KN, Richman DD, Hostetler KY. Beadle JR, et al. Among authors: aldern ka. Antivir Chem Chemother. 1998 Jan;9(1):33-40. doi: 10.1177/095632029800900104. Antivir Chem Chemother. 1998. PMID: 9875375

5

Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.

Beadle JR, Kini GD, Aldern KA, Gardner MF, Wright KN, Rybak RJ, Kern ER, Hostetler KY. Beadle JR, et al. Among authors: aldern ka. Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):471-9. doi: 10.1080/15257770008033022. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10772728

6

In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.

Hostetler KY, Rybak RJ, Beadle JR, Gardner MF, Aldern KA, Wright KN, Kern ER. Hostetler KY, et al. Among authors: aldern ka. Antivir Chem Chemother. 2001 Jan;12(1):61-70. doi: 10.1177/095632020101200104. Antivir Chem Chemother. 2001. PMID: 11437323 Free article.

7

Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.

Hostetler KY, Aldern KA, Wan WB, Ciesla SL, Beadle JR. Hostetler KY, et al. Among authors: aldern ka. Antimicrob Agents Chemother. 2006 Aug;50(8):2857-9. doi: 10.1128/AAC.01223-05. Antimicrob Agents Chemother. 2006. PMID: 16870786 Free PMC article.

8

Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.

Kini GD, Beadle JR, Xie H, Aldern KA, Richman DD, Hostetler KY. Kini GD, et al. Among authors: aldern ka. Antiviral Res. 1997 Sep;36(1):43-53. doi: 10.1016/s0166-3542(97)00039-9. Antiviral Res. 1997. PMID: 9330760

9

Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.

Beadle JR, Hartline C, Aldern KA, Rodriguez N, Harden E, Kern ER, Hostetler KY. Beadle JR, et al. Among authors: aldern ka. Antimicrob Agents Chemother. 2002 Aug;46(8):2381-6. doi: 10.1128/AAC.46.8.2381-2386.2002. Antimicrob Agents Chemother. 2002. PMID: 12121908 Free PMC article.

10

Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.

Aldern KA, Ciesla SL, Winegarden KL, Hostetler KY. Aldern KA, et al. Mol Pharmacol. 2003 Mar;63(3):678-81. doi: 10.1124/mol.63.3.678. Mol Pharmacol. 2003. PMID: 12606777

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