Baker R - Search Results

1

Approaches to rational drug development in Alzheimer's disease.

Iversen LL, Iversen SD, Freedman SB, Dawson G, Rupniak N, Hargreaves RJ, Showell GA, Street LJ, Baker R. Iversen LL, et al. Among authors: baker r. Drug Des Discov. 1993;9(3-4):251-9. Drug Des Discov. 1993. PMID: 8400006 Review. No abstract available.

2

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.

Showell GA, Baker R, Davis J, Hargreaves R, Freedman SB, Hoogsteen K, Patel S, Snow RJ. Showell GA, et al. Among authors: baker r. J Med Chem. 1992 Mar 6;35(5):911-6. doi: 10.1021/jm00083a016. J Med Chem. 1992. PMID: 1548680

3

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

Street LJ, Baker R, Book T, Kneen CO, MacLeod AM, Merchant KJ, Showell GA, Saunders J, Herbert RH, Freedman SB, et al. Street LJ, et al. Among authors: baker r. J Med Chem. 1990 Oct;33(10):2690-7. doi: 10.1021/jm00172a003. J Med Chem. 1990. PMID: 2213823

4

The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo.

Freedman SB, Dawson GR, Iversen LL, Baker R, Hargreaves RJ. Freedman SB, et al. Among authors: baker r. Life Sci. 1993;52(5-6):489-95. doi: 10.1016/0024-3205(93)90306-n. Life Sci. 1993. PMID: 8441329 Review.

5

L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.

Freedman SB, Patel S, Harley EA, Iversen LL, Baker R, Showell GA, Saunders J, McKnight A, Newberry N, Scholey K, et al. Freedman SB, et al. Among authors: baker r. Eur J Pharmacol. 1992 Apr 29;215(1):135-6. doi: 10.1016/0014-2999(92)90618-e. Eur J Pharmacol. 1992. PMID: 1516645

6

Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.

Street LJ, Baker R, Book T, Reeve AJ, Saunders J, Willson T, Marwood RS, Patel S, Freedman SB. Street LJ, et al. Among authors: baker r. J Med Chem. 1992 Jan 24;35(2):295-305. doi: 10.1021/jm00080a014. J Med Chem. 1992. PMID: 1732546

7

Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.

Showell GA, Gibbons TL, Kneen CO, MacLeod AM, Merchant K, Saunders J, Freedman SB, Patel S, Baker R. Showell GA, et al. Among authors: baker r. J Med Chem. 1991 Mar;34(3):1086-94. doi: 10.1021/jm00107a032. J Med Chem. 1991. PMID: 2002451

8

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.

Saunders J, Cassidy M, Freedman SB, Harley EA, Iversen LL, Kneen C, MacLeod AM, Merchant KJ, Snow RJ, Baker R. Saunders J, et al. Among authors: baker r. J Med Chem. 1990 Apr;33(4):1128-38. doi: 10.1021/jm00166a008. J Med Chem. 1990. PMID: 2319559

9

2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists.

Saunders J, Showell GA, Snow RJ, Baker R, Harley EA, Freedman SB. Saunders J, et al. Among authors: baker r. J Med Chem. 1988 Feb;31(2):486-91. doi: 10.1021/jm00397a039. J Med Chem. 1988. PMID: 3339620

10

High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.

Showell GA, Bourrain S, Neduvelil JG, Fletcher SR, Baker R, Watt AP, Fletcher AE, Freedman SB, Kemp JA, Marshall GR. Showell GA, et al. Among authors: baker r. J Med Chem. 1994 Mar 18;37(6):719-21. doi: 10.1021/jm00032a002. J Med Chem. 1994. PMID: 8145219 Review. No abstract available.

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