Hargreaves RJ - Search Results

1

Approaches to rational drug development in Alzheimer's disease.

Iversen LL, Iversen SD, Freedman SB, Dawson G, Rupniak N, Hargreaves RJ, Showell GA, Street LJ, Baker R. Iversen LL, et al. Among authors: hargreaves rj. Drug Des Discov. 1993;9(3-4):251-9. Drug Des Discov. 1993. PMID: 8400006 Review. No abstract available.

2

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.

Showell GA, Baker R, Davis J, Hargreaves R, Freedman SB, Hoogsteen K, Patel S, Snow RJ. Showell GA, et al. Among authors: hargreaves r. J Med Chem. 1992 Mar 6;35(5):911-6. doi: 10.1021/jm00083a016. J Med Chem. 1992. PMID: 1548680

3

The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo.

Freedman SB, Dawson GR, Iversen LL, Baker R, Hargreaves RJ. Freedman SB, et al. Among authors: hargreaves rj. Life Sci. 1993;52(5-6):489-95. doi: 10.1016/0024-3205(93)90306-n. Life Sci. 1993. PMID: 8441329 Review.

4

L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.

Hargreaves RJ, McKnight AT, Scholey K, Newberry NR, Street LJ, Hutson PH, Semark JE, Harley EA, Patel S, Freedman SB. Hargreaves RJ, et al. Br J Pharmacol. 1992 Oct;107(2):494-501. doi: 10.1111/j.1476-5381.1992.tb12773.x. Br J Pharmacol. 1992. PMID: 1422595 Free PMC article.

5

Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism.

Hargreaves RJ, Rigby M, Smith D, Hill RG, Iversen LL. Hargreaves RJ, et al. Neurochem Res. 1993 Dec;18(12):1263-9. doi: 10.1007/BF00975046. Neurochem Res. 1993. PMID: 7903796

6

Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

Patel S, Smith AJ, Chapman KL, Fletcher AE, Kemp JA, Marshall GR, Hargreaves RJ, Ryecroft W, Iversen LL, Iversen SD, et al. Patel S, et al. Among authors: hargreaves rj. Mol Pharmacol. 1994 Nov;46(5):943-8. Mol Pharmacol. 1994. PMID: 7969084

7

Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology.

Hargreaves RJ, Hill RG, Iversen LL. Hargreaves RJ, et al. Acta Neurochir Suppl (Wien). 1994;60:15-9. doi: 10.1007/978-3-7091-9334-1_4. Acta Neurochir Suppl (Wien). 1994. PMID: 7976530 Review.

8

A second generation of non-peptide cholecystokinin receptor antagonists and their possible therapeutic potential.

Freedman SB, Patel S, Smith AJ, Chapman K, Fletcher A, Kemp JA, Marshall GR, Hargreaves RJ, Scholey K, Mellin EC, et al. Freedman SB, et al. Among authors: hargreaves rj. Ann N Y Acad Sci. 1994 Mar 23;713:312-8. doi: 10.1111/j.1749-6632.1994.tb44079.x. Ann N Y Acad Sci. 1994. PMID: 8185173 Review.

9

L-694,247: a potent 5-HT1D receptor agonist.

Beer MS, Stanton JA, Bevan Y, Heald A, Reeve AJ, Street LJ, Matassa VG, Hargreaves RJ, Middlemiss DN. Beer MS, et al. Among authors: hargreaves rj. Br J Pharmacol. 1993 Nov;110(3):1196-200. doi: 10.1111/j.1476-5381.1993.tb13941.x. Br J Pharmacol. 1993. PMID: 8298808 Free PMC article.

10

MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.

Atack JR, Wafford KA, Street LJ, Dawson GR, Tye S, Van Laere K, Bormans G, Sanabria-Bohórquez SM, De Lepeleire I, de Hoon JN, Van Hecken A, Burns HD, McKernan RM, Murphy MG, Hargreaves RJ. Atack JR, et al. Among authors: hargreaves rj. J Psychopharmacol. 2011 Mar;25(3):314-28. doi: 10.1177/0269881109354927. Epub 2010 Feb 10. J Psychopharmacol. 2011. PMID: 20147571 Clinical Trial.

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