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Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.
Grover GJ, Mellström K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennström B, Mookhtiar K, Horvath R, Speelman J, Egan D, Baxter JD. Grover GJ, et al. Among authors: smith ma. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. doi: 10.1073/pnas.1633737100. Epub 2003 Jul 29. Proc Natl Acad Sci U S A. 2003. PMID: 12888625 Free PMC article.
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS. Ahmad S, et al. Among authors: smith ma. Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102. doi: 10.1016/j.bmcl.2003.10.003. Bioorg Med Chem Lett. 2004. PMID: 14684307
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P, Grover G, Smith MA, Beehler B, Giupponi L, Dickinson KE, Zhang H, Humphreys WG, Patel BP, Schwinden M, Stouch T, Cheng PT, Biller SA, Ewing WR, Gordon D, Robl JA, Tino JA. Li J, et al. Among authors: smith ma. J Med Chem. 2007 Nov 29;50(24):5890-3. doi: 10.1021/jm7010595. Epub 2007 Oct 31. J Med Chem. 2007. PMID: 17973363
3,159 results