Ohtsuka I - Search Results

1

Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.

Kimura T, Watanabe N, Matsui M, Hayashi K, Tanaka H, Ohtsuka I, Saeki T, Kogushi M, Kabayashi H, Akasaka K, et al. Kimura T, et al. Among authors: ohtsuka i. J Med Chem. 1993 May 28;36(11):1641-53. doi: 10.1021/jm00063a014. J Med Chem. 1993. PMID: 8496931

2

Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages.

Kogushi M, Tanaka H, Kobayashi H, Yamada T, Ohtsuka I, Kimura T, Saito I. Kogushi M, et al. Among authors: ohtsuka i. Jpn J Pharmacol. 1995 Jun;68(2):191-9. doi: 10.1254/jjp.68.191. Jpn J Pharmacol. 1995. PMID: 7563976 Free article.

3

Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits.

Tanaka H, Ohtsuka I, Kogushi M, Kimura T, Fujimori T, Saeki T, Hayashi K, Kobayashi H, Yamada T, Hiyoshi H, et al. Tanaka H, et al. Among authors: ohtsuka i. Atherosclerosis. 1994 Jun;107(2):187-201. doi: 10.1016/0021-9150(94)90020-5. Atherosclerosis. 1994. PMID: 7980693

4

Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.

Kimura T, Takase Y, Hayashi K, Tanaka H, Ohtsuka I, Saeki T, Kogushi M, Yamada T, Fujimori T, Saitou I, et al. Kimura T, et al. Among authors: ohtsuka i. J Med Chem. 1993 May 28;36(11):1630-40. doi: 10.1021/jm00063a013. J Med Chem. 1993. PMID: 8496930

5

Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits.

Kogushi M, Tanaka H, Ohtsuka I, Yamada T, Kobayashi H, Saeki T, Takada M, Hiyoshi H, Yanagimachi M, Kimura T, Yoshitake S, Saito I. Kogushi M, et al. Among authors: ohtsuka i. Atherosclerosis. 1996 Aug 2;124(2):203-10. doi: 10.1016/0021-9150(96)05831-5. Atherosclerosis. 1996. PMID: 8830933

6

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-coa reductase inhibitors.

Hiyoshi H, Yanagimachi M, Ito M, Ohtsuka I, Yoshida I, Saeki T, Tanaka H. Hiyoshi H, et al. Among authors: ohtsuka i. J Lipid Res. 2000 Jul;41(7):1136-44. J Lipid Res. 2000. PMID: 10884296 Free article.

7

The inhibitory effect of a novel antiatheromatous agent, E5050, on the intimal thickening of aorta in cholesterol-fed rabbit in vivo.

Saeki T, Ohtsuka I, Hashida R, Shiojiri H, Yamatsu I, Morisaki N, Saito Y. Saeki T, et al. Among authors: ohtsuka i. Jpn J Pharmacol. 1991 Jun;56(2):159-66. doi: 10.1254/jjp.56.159. Jpn J Pharmacol. 1991. PMID: 1880995 Free article.

8

The effect of structural differences in the reducing terminus of sugars on the binding affinity of carbohydrates and proteins analyzed using photoaffinity labeling.

Ohtsuka I, Sadakane Y, Higuchi M, Hada N, Hada J, Kakiuchi N, Sakushima A. Ohtsuka I, et al. Bioorg Med Chem. 2011 Jan 15;19(2):894-9. doi: 10.1016/j.bmc.2010.11.067. Epub 2010 Dec 4. Bioorg Med Chem. 2011. PMID: 21211984

9

The development of new molecular tools containing a chemically synthesized carbohydrate ligand for the elucidation of carbohydrate roles via photoaffinity labeling: carbohydrate-protein interactions are affected by the structures of the glycosidic bonds and the reducing-end sugar.

Ohtsuka I, Sadakane Y, Hada N, Higuchi M, Atsumi T, Kakiuchi N. Ohtsuka I, et al. Bioorg Med Chem. 2014 Aug 1;22(15):3829-37. doi: 10.1016/j.bmc.2014.06.049. Epub 2014 Jun 28. Bioorg Med Chem. 2014. PMID: 25012569

10

Synthesis of a new glycosphingolipid, neurosporaside, from Neurospora crassa.

Ohtsuka I, Hada N, Kanemaru M, Fujii T, Atsumi T, Kakiuchi N. Ohtsuka I, et al. Carbohydr Res. 2015 Mar 2;404:9-16. doi: 10.1016/j.carres.2014.11.018. Epub 2014 Dec 3. Carbohydr Res. 2015. PMID: 25659120

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