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Page 1
Anti-endotoxin activity of a novel synthetic lipid A analog.
Kawata T, Bristol JR, Rose JR, Rossignol DP, Christ WJ, Asano O, Dubuc GR, Gavin WE, Hawkins LD, Kishi Y, et al. Kawata T, et al. Among authors: gavin we. Prog Clin Biol Res. 1995;392:499-509. Prog Clin Biol Res. 1995. PMID: 8524958
E5531, a pure endotoxin antagonist of high potency.
Christ WJ, Asano O, Robidoux AL, Perez M, Wang Y, Dubuc GR, Gavin WE, Hawkins LD, McGuinness PD, Mullarkey MA, et al. Christ WJ, et al. Among authors: gavin we. Science. 1995 Apr 7;268(5207):80-3. doi: 10.1126/science.7701344. Science. 1995. PMID: 7701344
A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.
Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F. Hawkins LD, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):655-61. doi: 10.1124/jpet.300.2.655. J Pharmacol Exp Ther. 2002. PMID: 11805229 Clinical Trial.