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The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine.
Mol Pharmacol. 1996 Jan;49(1):198-206.
Mol Pharmacol. 1996.
PMID: 8569707
Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.
Parker EM, Izzarelli DG, Lewis-Higgins L, Palmer D, Shapiro RA.
Parker EM, et al. Among authors: izzarelli dg.
J Neurochem. 1996 Nov;67(5):2096-103. doi: 10.1046/j.1471-4159.1996.67052096.x.
J Neurochem. 1996.
PMID: 8863519
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Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Parker EM, Izzarelli DG, Nowak HP, Mahle CD, Iben LG, Wang J, Goldstein ME.
Parker EM, et al. Among authors: izzarelli dg.
Brain Res Mol Brain Res. 1995 Dec 28;34(2):179-89. doi: 10.1016/0169-328x(95)00159-p.
Brain Res Mol Brain Res. 1995.
PMID: 8750821
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Amino-caprolactam derivatives as gamma-secretase inhibitors.
Parker MF, Bronson JJ, Barten DM, Corsa JA, Du W, Felsenstein KM, Guss VL, Izzarelli D, Loo A, McElhone KE, Marcin LR, Padmanabha R, Pak R, Polson CT, Toyn JH, Varma S, Wang J, Wong V, Zheng M, Roberts SB.
Parker MF, et al.
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5790-5. doi: 10.1016/j.bmcl.2007.08.047. Epub 2007 Aug 26.
Bioorg Med Chem Lett. 2007.
PMID: 17869509
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