Szklarz GD - Search Results

1

Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.

Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL. Szklarz GD, et al. Arch Biochem Biophys. 1996 Mar 15;327(2):308-18. doi: 10.1006/abbi.1996.0127. Arch Biochem Biophys. 1996. PMID: 8619620

2

Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.

Szklarz GD, He YA, Halpert JR. Szklarz GD, et al. Biochemistry. 1995 Nov 7;34(44):14312-22. doi: 10.1021/bi00044a008. Biochemistry. 1995. PMID: 7578035

3

Application of 3-dimensional homology modeling of cytochrome P450 2B1 for interpretation of site-directed mutagenesis results.

Szklarz GD, Ornstein RL, Halpert JR. Szklarz GD, et al. J Biomol Struct Dyn. 1994 Aug;12(1):061-78. J Biomol Struct Dyn. 1994. PMID: 7848559

4

Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.

Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR. Hasler JA, et al. Among authors: szklarz gd. Mol Pharmacol. 1994 Aug;46(2):338-45. Mol Pharmacol. 1994. PMID: 8078495

5

Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation.

He K, He YA, Szklarz GD, Halpert JR, Correia MA. He K, et al. Among authors: szklarz gd. J Biol Chem. 1996 Oct 18;271(42):25864-72. doi: 10.1074/jbc.271.42.25864. J Biol Chem. 1996. PMID: 8824218 Free article.

6

Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.

He YQ, Szklarz GD, Halpert JR. He YQ, et al. Among authors: szklarz gd. Arch Biochem Biophys. 1996 Nov 1;335(1):152-60. doi: 10.1006/abbi.1996.0493. Arch Biochem Biophys. 1996. PMID: 8914846

7

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

He YA, He YQ, Szklarz GD, Halpert JR. He YA, et al. Among authors: szklarz gd. Biochemistry. 1997 Jul 22;36(29):8831-9. doi: 10.1021/bi970182i. Biochemistry. 1997. PMID: 9220969

8

Molecular modeling of cytochrome P450 3A4.

Szklarz GD, Halpert JR. Szklarz GD, et al. J Comput Aided Mol Des. 1997 May;11(3):265-72. doi: 10.1023/a:1007956612081. J Comput Aided Mol Des. 1997. PMID: 9263853

9

Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1.

Kent UM, Hanna IH, Szklarz GD, Vaz AD, Halpert JR, Bend JR, Hollenberg PF. Kent UM, et al. Among authors: szklarz gd. Biochemistry. 1997 Sep 30;36(39):11707-16. doi: 10.1021/bi971064y. Biochemistry. 1997. PMID: 9305960

10

Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450.

Szklarz GD, Halpert JR. Szklarz GD, et al. Life Sci. 1997;61(26):2507-20. doi: 10.1016/s0024-3205(97)00717-0. Life Sci. 1997. PMID: 9416773 Review.

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