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Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Buck IM, Black JW, Cooke T, Dunstone DJ, Gaffen JD, Griffin EP, Harper EA, Hull RA, Kalindjian SB, Lilley EJ, Linney ID, Low CM, McDonald IM, Pether MJ, Roberts SP, Shankley NP, Shaxted ME, Steel KI, Sykes DA, Tozer MJ, Watt GF, Walker MK, Wright L, Wright PT. Buck IM, et al. Among authors: low cm. J Med Chem. 2005 Nov 3;48(22):6803-12. doi: 10.1021/jm0490686. J Med Chem. 2005. PMID: 16250639
Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.
McDonald IM, Austin C, Buck IM, Dunstone DJ, Gaffen J, Griffin E, Harper EA, Hull RA, Kalindjian SB, Linney ID, Low CM, Patel D, Pether MJ, Raynor M, Roberts SP, Shaxted ME, Spencer J, Steel KI, Sykes DA, Wright PT, Xun W. McDonald IM, et al. Among authors: low cm. J Med Chem. 2007 Oct 4;50(20):4789-92. doi: 10.1021/jm0707626. Epub 2007 Sep 12. J Med Chem. 2007. PMID: 17850061
115 results