Denny WA - Search Results

1

Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.

Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA. Lee HH, et al. Among authors: denny wa. J Med Chem. 1996 Jun 21;39(13):2508-17. doi: 10.1021/jm9600104. J Med Chem. 1996. PMID: 8691448

2

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.

Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2003 Jan 2;46(1):169-82. doi: 10.1021/jm020367+. J Med Chem. 2003. PMID: 12502371

3

Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.

Tercel M, Stribbling SM, Sheppard H, Siim BG, Wu K, Pullen SM, Botting KJ, Wilson WR, Denny WA. Tercel M, et al. Among authors: denny wa. J Med Chem. 2003 May 22;46(11):2132-51. doi: 10.1021/jm020526p. J Med Chem. 2003. PMID: 12747786

4

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.

Hay MP, Atwell GJ, Wilson WR, Pullen SM, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2003 Jun 5;46(12):2456-66. doi: 10.1021/jm0205191. J Med Chem. 2003. PMID: 12773049

5

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.

Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2003 Dec 4;46(25):5533-45. doi: 10.1021/jm030308b. J Med Chem. 2003. PMID: 14640560

6

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.

Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2004 Jan 15;47(2):475-88. doi: 10.1021/jm030399c. J Med Chem. 2004. PMID: 14711317

7

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA. Helsby NA, et al. Among authors: denny wa. J Med Chem. 2004 Jun 3;47(12):3295-307. doi: 10.1021/jm0498699. J Med Chem. 2004. PMID: 15163209

8

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy.

Hay MP, Wilson WR, Denny WA. Hay MP, et al. Among authors: denny wa. Bioorg Med Chem. 2005 Jun 2;13(12):4043-55. doi: 10.1016/j.bmc.2005.03.055. Epub 2005 Apr 25. Bioorg Med Chem. 2005. PMID: 15911317

9

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: denny wa. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

10

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.

Hay MP, Hicks KO, Pruijn FB, Pchalek K, Siim BG, Wilson WR, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2007 Dec 13;50(25):6392-404. doi: 10.1021/jm070670g. Epub 2007 Nov 15. J Med Chem. 2007. PMID: 18001018

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