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Aromatic residue position on the nonpolar face of class a amphipathic helical peptides determines biological activity.
Datta G, Epand RF, Epand RM, Chaddha M, Kirksey MA, Garber DW, Lund-Katz S, Phillips MC, Hama S, Navab M, Fogelman AM, Palgunachari MN, Segrest JP, Anantharamaiah GM. Datta G, et al. Among authors: palgunachari mn. J Biol Chem. 2004 Jun 18;279(25):26509-17. doi: 10.1074/jbc.M314276200. Epub 2004 Apr 8. J Biol Chem. 2004. PMID: 15075321 Free article.
Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.
Nayyar G, Handattu SP, Monroe CE, Chaddha M, Datta G, Mishra VK, Keenum TD, Palgunachari MN, Garber DW, Anantharamaiah GM. Nayyar G, et al. Among authors: palgunachari mn. Atherosclerosis. 2010 Dec;213(2):449-57. doi: 10.1016/j.atherosclerosis.2010.09.030. Epub 2010 Oct 27. Atherosclerosis. 2010. PMID: 21030022 Free PMC article.
58 results