Locher HH - Search Results

1

Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone.

Locher HH, Schlunegger H, Hartman PG, Angehrn P, Then RL. Locher HH, et al. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81. doi: 10.1128/AAC.40.6.1376. Antimicrob Agents Chemother. 1996. PMID: 8726004 Free PMC article.

2

Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.

Wyss PC, Gerber P, Hartman PG, Hubschwerlen C, Locher H, Marty HP, Stahl M. Wyss PC, et al. J Med Chem. 2003 Jun 5;46(12):2304-12. doi: 10.1021/jm020495y. J Med Chem. 2003. PMID: 12773035

3

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

Dale GE, Broger C, D'Arcy A, Hartman PG, DeHoogt R, Jolidon S, Kompis I, Labhardt AM, Langen H, Locher H, Page MG, Stüber D, Then RL, Wipf B, Oefner C. Dale GE, et al. J Mol Biol. 1997 Feb 14;266(1):23-30. doi: 10.1006/jmbi.1996.0770. J Mol Biol. 1997. PMID: 9054967

4

The targets of currently used antibacterial agents: lessons for drug discovery.

Lange RP, Locher HH, Wyss PC, Then RL. Lange RP, et al. Among authors: locher hh. Curr Pharm Des. 2007;13(30):3140-54. doi: 10.2174/138161207782110408. Curr Pharm Des. 2007. PMID: 17979755 Review.

5

Peptide deformylase as an antibacterial drug target: target validation and resistance development.

Apfel CM, Locher H, Evers S, Takács B, Hubschwerlen C, Pirson W, Page MG, Keck W. Apfel CM, et al. Antimicrob Agents Chemother. 2001 Apr;45(4):1058-64. doi: 10.1128/AAC.45.4.1058-1064.2001. Antimicrob Agents Chemother. 2001. PMID: 11257016 Free PMC article.

6

In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.

Locher HH, Seiler P, Chen X, Schroeder S, Pfaff P, Enderlin M, Klenk A, Fournier E, Hubschwerlen C, Ritz D, Kelly CP, Keck W. Locher HH, et al. Antimicrob Agents Chemother. 2014;58(2):892-900. doi: 10.1128/AAC.01830-13. Epub 2013 Nov 25. Antimicrob Agents Chemother. 2014. PMID: 24277020 Free PMC article.

7

Dimers of nostocarboline with potent antibacterial activity.

Locher HH, Ritz D, Pfaff P, Gaertner M, Knezevic A, Sabato D, Schroeder S, Barbaras D, Gademann K. Locher HH, et al. Chemotherapy. 2010;56(4):318-24. doi: 10.1159/000320033. Epub 2010 Aug 13. Chemotherapy. 2010. PMID: 20714150 Free article.

8

Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide.

Sader HS, Rhomberg PR, Duncan LR, Locher HH, Dale GE, Flamm RK. Sader HS, et al. Among authors: locher hh. J Antimicrob Chemother. 2020 Jun 1;75(6):1518-1524. doi: 10.1093/jac/dkaa020. J Antimicrob Chemother. 2020. PMID: 32087024

9

Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.

Hubschwerlen C, Specklin JL, Baeschlin DK, Borer Y, Haefeli S, Sigwalt C, Schroeder S, Locher HH. Hubschwerlen C, et al. Among authors: locher hh. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4229-33. doi: 10.1016/j.bmcl.2003.07.028. Bioorg Med Chem Lett. 2003. PMID: 14623007

10

Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.

Locher HH, Caspers P, Bruyère T, Schroeder S, Pfaff P, Knezevic A, Keck W, Ritz D. Locher HH, et al. Antimicrob Agents Chemother. 2014;58(2):901-8. doi: 10.1128/AAC.01831-13. Epub 2013 Nov 25. Antimicrob Agents Chemother. 2014. PMID: 24277035 Free PMC article.

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