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Blood levels of transforming growth factor-beta 1 (TGF-beta1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon-beta 1b (IFN-beta1b).
Nicoletti F, Di Marco R, Patti F, Reggio E, Nicoletti A, Zaccone P, Stivala F, Meroni PL, Reggio A. Nicoletti F, et al. Clin Exp Immunol. 1998 Jul;113(1):96-9. doi: 10.1046/j.1365-2249.1998.00604.x. Clin Exp Immunol. 1998. PMID: 9697990 Free PMC article. Clinical Trial.
Short-term treatment of relapsing remitting multiple sclerosis patients with interferon (IFN)-beta1B transiently increases the blood levels of interleukin (IL)-6, IL-10 and IFN-gamma without significantly modifying those of IL-1beta, IL-2, IL-4 and tumour necrosis factor-alpha.
Nicoletti F, Di Marco R, Patti F, Zaccone P, L'Episcopo MR, Reggio E, Xiang M, Nicoletti A, Reggio A. Nicoletti F, et al. Cytokine. 2000 Jun;12(6):682-7. doi: 10.1006/cyto.1999.0616. Cytokine. 2000. PMID: 10843745
The antiinflammatory cytokine interleukin-13 is not detectable in the circulation of multiple sclerosis patients and is not inducible by interferon-beta1b treatment, that neither modifies its ex vivo secretion from peripheral blood mononuclear cells.
Nicoletti F, Di Marco R, Patti F, Nicoletti A, Leonardi C, Reggio E, Meroni P, Reggio A. Nicoletti F, et al. Autoimmunity. 2000 Dec;32(4):265-70. doi: 10.3109/08916930008994100. Autoimmunity. 2000. PMID: 11191285 Free article.
161 results