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Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.
Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, Rosenbrook W Jr, Herrin T, Li L, Madigan D, Vasavanonda S, Molla A, Saldivar A, McDonald E, Wideburg NE, Kempf D, Norbeck DW, Plattner JJ. Sham HL, et al. Among authors: kempf d. Biochem Biophys Res Commun. 1996 Aug 14;225(2):436-40. doi: 10.1006/bbrc.1996.1191. Biochem Biophys Res Commun. 1996. PMID: 8753780
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW. Zhao C, et al. Among authors: kempf dj. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5499-503. doi: 10.1016/j.bmcl.2005.08.093. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203141
Potent HIV-1 protease inhibitors with antiviral activities in vitro.
Sham HL, Betebenner DA, Wideburg NE, Saldivar AC, Kohlbrenner WE, Vasavanonda S, Kempf DJ, Norbeck DW, Zhao C, Clement JJ, et al. Sham HL, et al. Among authors: kempf dj. Biochem Biophys Res Commun. 1991 Mar 29;175(3):914-9. doi: 10.1016/0006-291x(91)91652-s. Biochem Biophys Res Commun. 1991. PMID: 2025263
Structure-based, C2 symmetric inhibitors of HIV protease.
Kempf DJ, Norbeck DW, Codacovi L, Wang XC, Kohlbrenner WE, Wideburg NE, Paul DA, Knigge MF, Vasavanonda S, Craig-Kennard A, et al. Kempf DJ, et al. J Med Chem. 1990 Oct;33(10):2687-9. doi: 10.1021/jm00172a002. J Med Chem. 1990. PMID: 2213822 No abstract available.
177 results