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Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.
Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, Rosenbrook W Jr, Herrin T, Li L, Madigan D, Vasavanonda S, Molla A, Saldivar A, McDonald E, Wideburg NE, Kempf D, Norbeck DW, Plattner JJ. Sham HL, et al. Among authors: marsh kc. Biochem Biophys Res Commun. 1996 Aug 14;225(2):436-40. doi: 10.1006/bbrc.1996.1191. Biochem Biophys Res Commun. 1996. PMID: 8753780
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW. Zhao C, et al. Among authors: marsh kc. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5499-503. doi: 10.1016/j.bmcl.2005.08.093. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203141
Design of orally bioavailable, symmetry-based inhibitors of HIV protease.
Kempf DJ, Marsh KC, Fino LC, Bryant P, Craig-Kennard A, Sham HL, Zhao C, Vasavanonda S, Kohlbrenner WE, Wideburg NE, et al. Kempf DJ, et al. Among authors: marsh kc. Bioorg Med Chem. 1994 Sep;2(9):847-58. doi: 10.1016/s0968-0896(00)82036-2. Bioorg Med Chem. 1994. PMID: 7712122
Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.
Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, McDonald E, Vasavanonda S, Wideburg N, Saldivar A, Robins T, et al. Sham HL, et al. Among authors: marsh kc. Biochem Biophys Res Commun. 1995 Jun 6;211(1):159-65. doi: 10.1006/bbrc.1995.1791. Biochem Biophys Res Commun. 1995. PMID: 7779082
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: marsh kc. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.
Kempf DJ, Marsh KC, Kumar G, Rodrigues AD, Denissen JF, McDonald E, Kukulka MJ, Hsu A, Granneman GR, Baroldi PA, Sun E, Pizzuti D, Plattner JJ, Norbeck DW, Leonard JM. Kempf DJ, et al. Among authors: marsh kc. Antimicrob Agents Chemother. 1997 Mar;41(3):654-60. doi: 10.1128/AAC.41.3.654. Antimicrob Agents Chemother. 1997. PMID: 9056009 Free PMC article.
224 results